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Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects.
Am Rev Respir Dis. 1992 Dec; 146(6):1506-10.AR

Abstract

The effect of indomethacin on the capacity of LTE4 to enhance airway histamine responsiveness was evaluated in eight mild asthmatic subjects. Subjects attended the laboratory on three separate pairs of study days when inhalation challenges with methacholine or LTE4 were performed and the airway responses to histamine were measured 4 and 7 h later. An open pair of study days was followed by a pair of study days during ingestion of either placebo or indomethacin capsules. The dose of agonist that produced a 35% fall in specific airways conductance (PD35 SGaw) was obtained by linear interpolation from the logarithmic dose-response curve. Indomethacin treatment did not affect baseline SGaw or methacholine airway responsiveness. However, indomethacin significantly inhibited LTE4-induced histamine hyperresponsiveness. Maximum enhancement of histamine responsiveness by LTE4 on the open and placebo study days was 4.1 +/- 0.9- (mean +/- SEM) and 5.7 +/- 1.2-fold, respectively (p = 0.36). Maximal enhancement on the indomethacin day was 1.68 +/- 0.46, and this was significantly decreased compared with that on the placebo day (p = 0.02). This suggests that LTE4-induced enhanced responsiveness to histamine is mediated in part by cyclooxygenase pathway-derived products.

Authors+Show Affiliations

Department of Allergy and Allied Respiratory Disorders, Guy's Hospital, London, England.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1333740

Citation

Christie, P E., et al. "Effect of Indomethacin On Leukotriene4-induced Histamine Hyperresponsiveness in Asthmatic Subjects." The American Review of Respiratory Disease, vol. 146, no. 6, 1992, pp. 1506-10.
Christie PE, Hawksworth R, Spur BW, et al. Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects. Am Rev Respir Dis. 1992;146(6):1506-10.
Christie, P. E., Hawksworth, R., Spur, B. W., & Lee, T. H. (1992). Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects. The American Review of Respiratory Disease, 146(6), 1506-10.
Christie PE, et al. Effect of Indomethacin On Leukotriene4-induced Histamine Hyperresponsiveness in Asthmatic Subjects. Am Rev Respir Dis. 1992;146(6):1506-10. PubMed PMID: 1333740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects. AU - Christie,P E, AU - Hawksworth,R, AU - Spur,B W, AU - Lee,T H, PY - 1992/12/1/pubmed PY - 1992/12/1/medline PY - 1992/12/1/entrez SP - 1506 EP - 10 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 146 IS - 6 N2 - The effect of indomethacin on the capacity of LTE4 to enhance airway histamine responsiveness was evaluated in eight mild asthmatic subjects. Subjects attended the laboratory on three separate pairs of study days when inhalation challenges with methacholine or LTE4 were performed and the airway responses to histamine were measured 4 and 7 h later. An open pair of study days was followed by a pair of study days during ingestion of either placebo or indomethacin capsules. The dose of agonist that produced a 35% fall in specific airways conductance (PD35 SGaw) was obtained by linear interpolation from the logarithmic dose-response curve. Indomethacin treatment did not affect baseline SGaw or methacholine airway responsiveness. However, indomethacin significantly inhibited LTE4-induced histamine hyperresponsiveness. Maximum enhancement of histamine responsiveness by LTE4 on the open and placebo study days was 4.1 +/- 0.9- (mean +/- SEM) and 5.7 +/- 1.2-fold, respectively (p = 0.36). Maximal enhancement on the indomethacin day was 1.68 +/- 0.46, and this was significantly decreased compared with that on the placebo day (p = 0.02). This suggests that LTE4-induced enhanced responsiveness to histamine is mediated in part by cyclooxygenase pathway-derived products. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/1333740/Effect_of_indomethacin_on_leukotriene4_induced_histamine_hyperresponsiveness_in_asthmatic_subjects_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/146.6.1506?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -