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Superoxide dismutase activity in cataractous lenses.
Jpn J Ophthalmol. 1992; 36(3):273-80.JJ

Abstract

The relationship between free oxygen radicals and cataract formation has been discussed. The behavior in lenses of the enzyme superoxide dismutase (SOD), which eliminates active oxygen, and glutathione (GSH), which has a defensive action against cataract, were investigated. SOD activity in human cataractous lenses and in porcine lenses was measured by electron spin resonance spectrometry. GSH was measured by high performance liquid chromatography. SOD and GSH significantly decreased in human lenses with senile cataracts as the cataracts advanced. The SOD and GSH values showed a positive correlation. The SOD activity in human lenses was localized dominantly in the lens epithelium and was also found in the shallow layer of the cortex. SOD activity appears to act as a barrier against photooxidation.

Authors+Show Affiliations

Department of Ophthalmology, Kawasaki Hospital, Kawasaki Medical School, Okayama, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1334522

Citation

Fujiwara, H, et al. "Superoxide Dismutase Activity in Cataractous Lenses." Japanese Journal of Ophthalmology, vol. 36, no. 3, 1992, pp. 273-80.
Fujiwara H, Takigawa Y, Suzuki T, et al. Superoxide dismutase activity in cataractous lenses. Jpn J Ophthalmol. 1992;36(3):273-80.
Fujiwara, H., Takigawa, Y., Suzuki, T., & Nakata, K. (1992). Superoxide dismutase activity in cataractous lenses. Japanese Journal of Ophthalmology, 36(3), 273-80.
Fujiwara H, et al. Superoxide Dismutase Activity in Cataractous Lenses. Jpn J Ophthalmol. 1992;36(3):273-80. PubMed PMID: 1334522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Superoxide dismutase activity in cataractous lenses. AU - Fujiwara,H, AU - Takigawa,Y, AU - Suzuki,T, AU - Nakata,K, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 273 EP - 80 JF - Japanese journal of ophthalmology JO - Jpn J Ophthalmol VL - 36 IS - 3 N2 - The relationship between free oxygen radicals and cataract formation has been discussed. The behavior in lenses of the enzyme superoxide dismutase (SOD), which eliminates active oxygen, and glutathione (GSH), which has a defensive action against cataract, were investigated. SOD activity in human cataractous lenses and in porcine lenses was measured by electron spin resonance spectrometry. GSH was measured by high performance liquid chromatography. SOD and GSH significantly decreased in human lenses with senile cataracts as the cataracts advanced. The SOD and GSH values showed a positive correlation. The SOD activity in human lenses was localized dominantly in the lens epithelium and was also found in the shallow layer of the cortex. SOD activity appears to act as a barrier against photooxidation. SN - 0021-5155 UR - https://www.unboundmedicine.com/medline/citation/1334522/Superoxide_dismutase_activity_in_cataractous_lenses_ L2 - https://medlineplus.gov/cataract.html DB - PRIME DP - Unbound Medicine ER -