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Participation of GABAergic systems in the production of antinociception by various stresses in mice.
Jpn J Pharmacol. 1992 Oct; 60(2):105-10.JJ

Abstract

Based on the data that diazepam, a benzodiazepine (BZP) receptor agonist, antagonized psychological (PSY)-stress induced analgesia (SIA) without prominent action on footshock (FS)- and forced swimming (SW)-SIA and that BZP receptors are coupled with GABA receptors, we examined how the GABAergic system participates in the production of various SIAs. Muscimol, a GABAA receptor agonist, at doses of 0.25 to 1.0 mg/kg, affected each SIA differently, suppressed PSY-SIA at 0.25 mg/kg but tended to potentiate it at 1.0 mg/kg, potentiated SW-SIA dose-dependently and did not affect FS-SIA at the doses employed. Both bicuculline, a GABAA receptor antagonist, 0.5 to 2.0 mg/kg, and picrotoxin, a Cl- channel blocker, 0.25 to 1.0 mg/kg, dose-dependently suppressed PSY- and FS-SIA. Meanwhile, the effects of both drugs on SW-SIA were less than those on PSY- and FS-SIA, namely, bicuculline slightly inhibited it only at 2.0 mg/kg, and picrotoxin did not produce any appreciable effect even at the highest dose. Baclofen, a GABAB receptor agonist, at 5.0 and 10.0 mg/kg had no influence on each SIA. On the contrary, CGP 35348, a GABAB receptor antagonist at 20 to 100 mg/kg caused the dose-dependent blockade of FS-SIA, but affected neither PSY- nor SW-SIA. The production of PSY- and SW-SIA is attributable to the GABAA receptors/Cl- channel mediated mechanism alone, while that of FS-SIA involves both GABAA and GABAB receptor mediated systems. Thus, GABAergic systems play an important role in the production of each SIA; however, the participation of the receptor subtypes in the mechanism was different from each other.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1336079

Citation

Tokuyama, S, et al. "Participation of GABAergic Systems in the Production of Antinociception By Various Stresses in Mice." Japanese Journal of Pharmacology, vol. 60, no. 2, 1992, pp. 105-10.
Tokuyama S, Takahashi M, Kaneto H. Participation of GABAergic systems in the production of antinociception by various stresses in mice. Jpn J Pharmacol. 1992;60(2):105-10.
Tokuyama, S., Takahashi, M., & Kaneto, H. (1992). Participation of GABAergic systems in the production of antinociception by various stresses in mice. Japanese Journal of Pharmacology, 60(2), 105-10.
Tokuyama S, Takahashi M, Kaneto H. Participation of GABAergic Systems in the Production of Antinociception By Various Stresses in Mice. Jpn J Pharmacol. 1992;60(2):105-10. PubMed PMID: 1336079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Participation of GABAergic systems in the production of antinociception by various stresses in mice. AU - Tokuyama,S, AU - Takahashi,M, AU - Kaneto,H, PY - 1992/10/1/pubmed PY - 1992/10/1/medline PY - 1992/10/1/entrez SP - 105 EP - 10 JF - Japanese journal of pharmacology JO - Jpn J Pharmacol VL - 60 IS - 2 N2 - Based on the data that diazepam, a benzodiazepine (BZP) receptor agonist, antagonized psychological (PSY)-stress induced analgesia (SIA) without prominent action on footshock (FS)- and forced swimming (SW)-SIA and that BZP receptors are coupled with GABA receptors, we examined how the GABAergic system participates in the production of various SIAs. Muscimol, a GABAA receptor agonist, at doses of 0.25 to 1.0 mg/kg, affected each SIA differently, suppressed PSY-SIA at 0.25 mg/kg but tended to potentiate it at 1.0 mg/kg, potentiated SW-SIA dose-dependently and did not affect FS-SIA at the doses employed. Both bicuculline, a GABAA receptor antagonist, 0.5 to 2.0 mg/kg, and picrotoxin, a Cl- channel blocker, 0.25 to 1.0 mg/kg, dose-dependently suppressed PSY- and FS-SIA. Meanwhile, the effects of both drugs on SW-SIA were less than those on PSY- and FS-SIA, namely, bicuculline slightly inhibited it only at 2.0 mg/kg, and picrotoxin did not produce any appreciable effect even at the highest dose. Baclofen, a GABAB receptor agonist, at 5.0 and 10.0 mg/kg had no influence on each SIA. On the contrary, CGP 35348, a GABAB receptor antagonist at 20 to 100 mg/kg caused the dose-dependent blockade of FS-SIA, but affected neither PSY- nor SW-SIA. The production of PSY- and SW-SIA is attributable to the GABAA receptors/Cl- channel mediated mechanism alone, while that of FS-SIA involves both GABAA and GABAB receptor mediated systems. Thus, GABAergic systems play an important role in the production of each SIA; however, the participation of the receptor subtypes in the mechanism was different from each other. SN - 0021-5198 UR - https://www.unboundmedicine.com/medline/citation/1336079/Participation_of_GABAergic_systems_in_the_production_of_antinociception_by_various_stresses_in_mice_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/jphs1951/60.105?from=PubMed DB - PRIME DP - Unbound Medicine ER -