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Borage or primrose oil added to standardized diets are equivalent sources for gamma-linolenic acid in rats.
Lipids. 1992 Dec; 27(12):1018-23.L

Abstract

The aim of this study was to evaluate the effect of different doses and sources of dietary gamma-linolenic acid (GLA) on the tissue phospholipid fatty acid composition. Rats fed four different levels of GLA (2.3, 4.6, 6.4 and 16.2 g of GLA/kg diet) in the form of either borage oil or evening primrose oil during 6 wk were compared with animals fed corn oil. The levels of dihomo-gamma-linolenic acid (DHLA) and GLA showed a significant dose-related increase in liver, erythrocyte and aorta phospholipids. Moreover, the arachidonic acid/DHLA ratios in tissues decreased with increasing intake of dietary GLA. There was no significant difference in tissue GLA and DHLA levels within groups given equal amounts of dietary GLA either as borage oil or evening primrose oil. The amount of dietary GLA administered did not significantly influence prostaglandin E2 production in stimulated aortic rings and thromboxane B2 levels in serum; however, an increase in prostaglandin E1 derived from DHLA was observed in the supernatants of stimulated aorta.

Authors+Show Affiliations

F. Hoffmann-La Roche Ltd., Department of Vitamin and Nutrition Research, Basel, Switzerland.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1336802

Citation

Raederstorff, D, and U Moser. "Borage or Primrose Oil Added to Standardized Diets Are Equivalent Sources for Gamma-linolenic Acid in Rats." Lipids, vol. 27, no. 12, 1992, pp. 1018-23.
Raederstorff D, Moser U. Borage or primrose oil added to standardized diets are equivalent sources for gamma-linolenic acid in rats. Lipids. 1992;27(12):1018-23.
Raederstorff, D., & Moser, U. (1992). Borage or primrose oil added to standardized diets are equivalent sources for gamma-linolenic acid in rats. Lipids, 27(12), 1018-23.
Raederstorff D, Moser U. Borage or Primrose Oil Added to Standardized Diets Are Equivalent Sources for Gamma-linolenic Acid in Rats. Lipids. 1992;27(12):1018-23. PubMed PMID: 1336802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Borage or primrose oil added to standardized diets are equivalent sources for gamma-linolenic acid in rats. AU - Raederstorff,D, AU - Moser,U, PY - 1992/12/1/pubmed PY - 1992/12/1/medline PY - 1992/12/1/entrez SP - 1018 EP - 23 JF - Lipids JO - Lipids VL - 27 IS - 12 N2 - The aim of this study was to evaluate the effect of different doses and sources of dietary gamma-linolenic acid (GLA) on the tissue phospholipid fatty acid composition. Rats fed four different levels of GLA (2.3, 4.6, 6.4 and 16.2 g of GLA/kg diet) in the form of either borage oil or evening primrose oil during 6 wk were compared with animals fed corn oil. The levels of dihomo-gamma-linolenic acid (DHLA) and GLA showed a significant dose-related increase in liver, erythrocyte and aorta phospholipids. Moreover, the arachidonic acid/DHLA ratios in tissues decreased with increasing intake of dietary GLA. There was no significant difference in tissue GLA and DHLA levels within groups given equal amounts of dietary GLA either as borage oil or evening primrose oil. The amount of dietary GLA administered did not significantly influence prostaglandin E2 production in stimulated aortic rings and thromboxane B2 levels in serum; however, an increase in prostaglandin E1 derived from DHLA was observed in the supernatants of stimulated aorta. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/1336802/Borage_or_primrose_oil_added_to_standardized_diets_are_equivalent_sources_for_gamma_linolenic_acid_in_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0024-4201&date=1992&volume=27&issue=12&spage=1018 DB - PRIME DP - Unbound Medicine ER -