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Clinical comparative study of azithromycin versus erythromycin in the treatment of acute respiratory tract infections in children.
J Chemother. 1992 Dec; 4(6):364-70.JC

Abstract

The efficacy and tolerability of azithromycin and erythromycin in the treatment of acute respiratory tract infections in children were compared in an open, multicenter, randomized trial. A total of 151 children, aged from 2 months to 14 years, suffering from upper airways infections (60), or lower respiratory tract infections (91), were randomized to be treated either with azithromycin, 10 mg/Kg/day per os once daily for 3 or 10 mg/Kg/day 1 and 5 mg/Kg/days 2-5 (77 patients) or with erythromycin, 50 mg/Kg/day thrice daily for at least 7 days (74 patients). The two treatment groups did not significantly differ as to sex, age, weight, type and severity of infection, and infecting pathogens. Clinical evaluation was performed prior to therapy, on treatment days 1, 3, 5 and 7, and on day 10. Microbiological and laboratory assessment were carried out at baseline and after the end of therapeutic course. Chest X-ray and serologic assays for Mycoplasma pneumoniae infection were obtained in patients suspected to have lower respiratory tract infections. At the end of therapy, clinical cure was achieved in 73 out of 77 patients (94.8%) in the azithromycin group, and in 60/72 evaluable subjects (83.3%) in the erythromycin group. A significantly more rapid remission of several illness-related signs and symptoms was observed in patients treated with azithromycin. A total of 75 bacterial pathogens were isolated at baseline microbiological examination; at the end of the therapeutic course bacteriological eradication was obtained in 34/34 cases (100%) treated with azithromycin, and in 40/41 children (97.5%) treated with erythromycin.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Istituto Malattie Infettive, Università di Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

1337553

Citation

Manfredi, R, et al. "Clinical Comparative Study of Azithromycin Versus Erythromycin in the Treatment of Acute Respiratory Tract Infections in Children." Journal of Chemotherapy (Florence, Italy), vol. 4, no. 6, 1992, pp. 364-70.
Manfredi R, Jannuzzi C, Mantero E, et al. Clinical comparative study of azithromycin versus erythromycin in the treatment of acute respiratory tract infections in children. J Chemother. 1992;4(6):364-70.
Manfredi, R., Jannuzzi, C., Mantero, E., Longo, L., Schiavone, R., Tempesta, A., Pavesio, D., Pecco, P., & Chiodo, F. (1992). Clinical comparative study of azithromycin versus erythromycin in the treatment of acute respiratory tract infections in children. Journal of Chemotherapy (Florence, Italy), 4(6), 364-70.
Manfredi R, et al. Clinical Comparative Study of Azithromycin Versus Erythromycin in the Treatment of Acute Respiratory Tract Infections in Children. J Chemother. 1992;4(6):364-70. PubMed PMID: 1337553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical comparative study of azithromycin versus erythromycin in the treatment of acute respiratory tract infections in children. AU - Manfredi,R, AU - Jannuzzi,C, AU - Mantero,E, AU - Longo,L, AU - Schiavone,R, AU - Tempesta,A, AU - Pavesio,D, AU - Pecco,P, AU - Chiodo,F, PY - 1992/12/1/pubmed PY - 1992/12/1/medline PY - 1992/12/1/entrez SP - 364 EP - 70 JF - Journal of chemotherapy (Florence, Italy) JO - J Chemother VL - 4 IS - 6 N2 - The efficacy and tolerability of azithromycin and erythromycin in the treatment of acute respiratory tract infections in children were compared in an open, multicenter, randomized trial. A total of 151 children, aged from 2 months to 14 years, suffering from upper airways infections (60), or lower respiratory tract infections (91), were randomized to be treated either with azithromycin, 10 mg/Kg/day per os once daily for 3 or 10 mg/Kg/day 1 and 5 mg/Kg/days 2-5 (77 patients) or with erythromycin, 50 mg/Kg/day thrice daily for at least 7 days (74 patients). The two treatment groups did not significantly differ as to sex, age, weight, type and severity of infection, and infecting pathogens. Clinical evaluation was performed prior to therapy, on treatment days 1, 3, 5 and 7, and on day 10. Microbiological and laboratory assessment were carried out at baseline and after the end of therapeutic course. Chest X-ray and serologic assays for Mycoplasma pneumoniae infection were obtained in patients suspected to have lower respiratory tract infections. At the end of therapy, clinical cure was achieved in 73 out of 77 patients (94.8%) in the azithromycin group, and in 60/72 evaluable subjects (83.3%) in the erythromycin group. A significantly more rapid remission of several illness-related signs and symptoms was observed in patients treated with azithromycin. A total of 75 bacterial pathogens were isolated at baseline microbiological examination; at the end of the therapeutic course bacteriological eradication was obtained in 34/34 cases (100%) treated with azithromycin, and in 40/41 children (97.5%) treated with erythromycin.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1120-009X UR - https://www.unboundmedicine.com/medline/citation/1337553/Clinical_comparative_study_of_azithromycin_versus_erythromycin_in_the_treatment_of_acute_respiratory_tract_infections_in_children_ L2 - https://medlineplus.gov/bacterialinfections.html DB - PRIME DP - Unbound Medicine ER -