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Free radicals in physiology and pathology.
Boll Soc Ital Biol Sper 1992 Aug-Sep; 68(8-9):491-511BS

Abstract

Free radicals are molecules with odd number of electrons and a high instability. Free radicals, which can occur in both organic (i.e., quinones) and inorganic molecules (i.e., O2-), are very reactive and their reactions are critical for the normal activity of a wide spectrum of biologic processes. They are also produced in the catalytic action of a variety of cellular enzymes and electron transport processes and are implicated in a number of physiologic and pathologic processes. Organisms can be exposed to free radicals in many ways other than through the processes of normal metabolism. Irradiation of organisms with electromagnetic radiation generates primary radicals (e-aq, OH., and H.), which can then undergo secondary reactions with dissolved O2 or with cellular solutes. In addition, a wide variety of environmental agents (drugs capable of redox cycling, and xenobiotics that can form free radical metabolites) including the aging process cause free radical damage to cells. This review deals with the reactions they can undergo and discusses the free radicals related to toxicology.

Authors+Show Affiliations

Department of Experimental Medicine and Oncology, University or Torino.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1338184

Citation

Dianzani, M U.. "Free Radicals in Physiology and Pathology." Bollettino Della Societa Italiana Di Biologia Sperimentale, vol. 68, no. 8-9, 1992, pp. 491-511.
Dianzani MU. Free radicals in physiology and pathology. Boll Soc Ital Biol Sper. 1992;68(8-9):491-511.
Dianzani, M. U. (1992). Free radicals in physiology and pathology. Bollettino Della Societa Italiana Di Biologia Sperimentale, 68(8-9), pp. 491-511.
Dianzani MU. Free Radicals in Physiology and Pathology. Boll Soc Ital Biol Sper. 1992;68(8-9):491-511. PubMed PMID: 1338184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Free radicals in physiology and pathology. A1 - Dianzani,M U, PY - 1992/8/1/pubmed PY - 1992/8/1/medline PY - 1992/8/1/entrez SP - 491 EP - 511 JF - Bollettino della Societa italiana di biologia sperimentale JO - Boll. Soc. Ital. Biol. Sper. VL - 68 IS - 8-9 N2 - Free radicals are molecules with odd number of electrons and a high instability. Free radicals, which can occur in both organic (i.e., quinones) and inorganic molecules (i.e., O2-), are very reactive and their reactions are critical for the normal activity of a wide spectrum of biologic processes. They are also produced in the catalytic action of a variety of cellular enzymes and electron transport processes and are implicated in a number of physiologic and pathologic processes. Organisms can be exposed to free radicals in many ways other than through the processes of normal metabolism. Irradiation of organisms with electromagnetic radiation generates primary radicals (e-aq, OH., and H.), which can then undergo secondary reactions with dissolved O2 or with cellular solutes. In addition, a wide variety of environmental agents (drugs capable of redox cycling, and xenobiotics that can form free radical metabolites) including the aging process cause free radical damage to cells. This review deals with the reactions they can undergo and discusses the free radicals related to toxicology. SN - 0037-8771 UR - https://www.unboundmedicine.com/medline/citation/1338184/Free_radicals_in_physiology_and_pathology_ DB - PRIME DP - Unbound Medicine ER -