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The inhibitory action of chlorogenic acid on the intestinal iron absorption in rats.

Abstract

The polyphenols are part of the composition of many foods, it is known the inhibitory effect of tea and coffee through the tannins on iron intestinal absorption; the "yerba mate" (Ilex Paraguarensis) is a beverage widely used in South America, that has a high content of a polyphenol named chlorogenic acid. The present work shows the effect of this substance in nonhem iron absorption. An intestinal loop, was made in rats, to form a closed cavity in a small section of intestine tieing it from the pilorous to a distance of six cm. In this closed cavity a solution of 59Fe was injected with different doses of chlorogenic acid; it was living 20, 40 and 120 minutes into the loop, and after this different times, the blood, spleen, liver, femur and intestine were removed to measure the 59Fe uptake to be compared with the control group. The results gave an intense inhibitory effect on the intestinal iron absorption with doses of 0.58 and 1.7 mM per rat of chlorogenic acid at the different times studied.

Authors+Show Affiliations

Centro de Estudios Farmacológicos y Botánicos, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1343584

Citation

Gutnisky, A, et al. "The Inhibitory Action of Chlorogenic Acid On the Intestinal Iron Absorption in Rats." Acta Physiologica, Pharmacologica Et Therapeutica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y [de] La Asociacion Latinoamericana De Farmacologia, vol. 42, no. 3, 1992, pp. 139-46.
Gutnisky A, Rizzo N, Castro ME, et al. The inhibitory action of chlorogenic acid on the intestinal iron absorption in rats. Acta Physiol Pharmacol Ther Latinoam. 1992;42(3):139-46.
Gutnisky, A., Rizzo, N., Castro, M. E., & Garbossa, G. (1992). The inhibitory action of chlorogenic acid on the intestinal iron absorption in rats. Acta Physiologica, Pharmacologica Et Therapeutica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y [de] La Asociacion Latinoamericana De Farmacologia, 42(3), 139-46.
Gutnisky A, et al. The Inhibitory Action of Chlorogenic Acid On the Intestinal Iron Absorption in Rats. Acta Physiol Pharmacol Ther Latinoam. 1992;42(3):139-46. PubMed PMID: 1343584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The inhibitory action of chlorogenic acid on the intestinal iron absorption in rats. AU - Gutnisky,A, AU - Rizzo,N, AU - Castro,M E, AU - Garbossa,G, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 139 EP - 46 JF - Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia JO - Acta Physiol Pharmacol Ther Latinoam VL - 42 IS - 3 N2 - The polyphenols are part of the composition of many foods, it is known the inhibitory effect of tea and coffee through the tannins on iron intestinal absorption; the "yerba mate" (Ilex Paraguarensis) is a beverage widely used in South America, that has a high content of a polyphenol named chlorogenic acid. The present work shows the effect of this substance in nonhem iron absorption. An intestinal loop, was made in rats, to form a closed cavity in a small section of intestine tieing it from the pilorous to a distance of six cm. In this closed cavity a solution of 59Fe was injected with different doses of chlorogenic acid; it was living 20, 40 and 120 minutes into the loop, and after this different times, the blood, spleen, liver, femur and intestine were removed to measure the 59Fe uptake to be compared with the control group. The results gave an intense inhibitory effect on the intestinal iron absorption with doses of 0.58 and 1.7 mM per rat of chlorogenic acid at the different times studied. SN - 0327-6309 UR - https://www.unboundmedicine.com/medline/citation/1343584/The_inhibitory_action_of_chlorogenic_acid_on_the_intestinal_iron_absorption_in_rats_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -