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Fixed dose combination short course chemotherapy in the treatment of pulmonary tuberculosis.
Ethiop Med J 1992; 30(2):63-8EM

Abstract

In this study two highly effective chemotherapeutic regimens of 6 and 8 months duration were studied and compared with the standard 12 month therapy under full supervision at the National TB Centre and St. Peter's TB Hospital in Addis Abeba. Patients with direct smear positive pulmonary tuberculosis were admitted to hospital during the initial phase of treatment for two months. At two months, sputum conversion rates, by direct smear and culture respectively, were 82% and 80% on Rifater, and 86 or 88% and 86% on the regimens containing separate preparations of isoniazid rifampicin and pyrazinamide, compared to 60% and 30% on the standard regimen. It was concluded that short course regimens of six or eight months with drugs either in combined form or separate preparations are more effective than the standard regimen.

Authors+Show Affiliations

St. Paul's Hospital, Addis Abeba, Ethiopia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1345030

Citation

Wolde, K, et al. "Fixed Dose Combination Short Course Chemotherapy in the Treatment of Pulmonary Tuberculosis." Ethiopian Medical Journal, vol. 30, no. 2, 1992, pp. 63-8.
Wolde K, Lema E, Roscigno G, et al. Fixed dose combination short course chemotherapy in the treatment of pulmonary tuberculosis. Ethiop Med J. 1992;30(2):63-8.
Wolde, K., Lema, E., Roscigno, G., & Abdi, A. (1992). Fixed dose combination short course chemotherapy in the treatment of pulmonary tuberculosis. Ethiopian Medical Journal, 30(2), pp. 63-8.
Wolde K, et al. Fixed Dose Combination Short Course Chemotherapy in the Treatment of Pulmonary Tuberculosis. Ethiop Med J. 1992;30(2):63-8. PubMed PMID: 1345030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fixed dose combination short course chemotherapy in the treatment of pulmonary tuberculosis. AU - Wolde,K, AU - Lema,E, AU - Roscigno,G, AU - Abdi,A, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 63 EP - 8 JF - Ethiopian medical journal JO - Ethiop. Med. J. VL - 30 IS - 2 N2 - In this study two highly effective chemotherapeutic regimens of 6 and 8 months duration were studied and compared with the standard 12 month therapy under full supervision at the National TB Centre and St. Peter's TB Hospital in Addis Abeba. Patients with direct smear positive pulmonary tuberculosis were admitted to hospital during the initial phase of treatment for two months. At two months, sputum conversion rates, by direct smear and culture respectively, were 82% and 80% on Rifater, and 86 or 88% and 86% on the regimens containing separate preparations of isoniazid rifampicin and pyrazinamide, compared to 60% and 30% on the standard regimen. It was concluded that short course regimens of six or eight months with drugs either in combined form or separate preparations are more effective than the standard regimen. SN - 0014-1755 UR - https://www.unboundmedicine.com/medline/citation/1345030/Fixed_dose_combination_short_course_chemotherapy_in_the_treatment_of_pulmonary_tuberculosis_ L2 - http://www.diseaseinfosearch.org/result/7252 DB - PRIME DP - Unbound Medicine ER -