Gastroesophageal reflux: diagnosis and management.Hosp Pract (Off Ed) 1992; 27(1):59-66HP
The pathologic potential of chronic esophagitis cannot be overemphasized. Persistent reflux causing cycles of mucosal damage followed by healing may eventually lead to end-stage disease, with development of peptic stricture. The most effective drugs available are those that inhibit acid production. Drugs that will enhance lower esophageal function are still in the future.