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Further studies on the adjuvant for dried BCG vaccine.
Bull World Health Organ 1957; 17(2):255-74BW

Abstract

The authors describe some recent investigations undertaken in Japan with the object of finding an adjuvant for dried BCG vaccine which would make it possible for the vaccine to be stored at room temperature in tropical countries without suffering any serious loss of viability.The first series of experiments, carried out with sodium glutamate as adjuvant, was designed to determine the effect of the concentration of adjuvant, the concentration of bacilli, the pH of the bacterial suspension, and the method of freeze-drying on the preservability of the vaccine. The sucrose vaccine in current use in Japan served as a control. In the light of the results, the authors make certain suggestions as to the optimum conditions for freeze-drying, but they stress that their proposals are tentative and that further research on the subject is needed.In the second series of experiments the authors investigated the adjuvant properties of certain organic acids known to be involved in the metabolic reactions of the tubercle bacillus. Reasonably good results were obtained with alpha-ketoglutaric, malic, lactic, and citric acids, but none of these substances proved to be as satisfactory an adjuvant as sodium glutamate for storage at 37 degrees C.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

13489467

Citation

OBAYASHI, Y, and C CHO. "Further Studies On the Adjuvant for Dried BCG Vaccine." Bulletin of the World Health Organization, vol. 17, no. 2, 1957, pp. 255-74.
OBAYASHI Y, CHO C. Further studies on the adjuvant for dried BCG vaccine. Bull World Health Organ. 1957;17(2):255-74.
OBAYASHI, Y., & CHO, C. (1957). Further studies on the adjuvant for dried BCG vaccine. Bulletin of the World Health Organization, 17(2), pp. 255-74.
OBAYASHI Y, CHO C. Further Studies On the Adjuvant for Dried BCG Vaccine. Bull World Health Organ. 1957;17(2):255-74. PubMed PMID: 13489467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further studies on the adjuvant for dried BCG vaccine. AU - OBAYASHI,Y, AU - CHO,C, PY - 1957/1/1/pubmed PY - 1957/1/1/medline PY - 1957/1/1/entrez KW - BCG VACCINATION KW - GLUTAMATES SP - 255 EP - 74 JF - Bulletin of the World Health Organization JO - Bull. World Health Organ. VL - 17 IS - 2 N2 - The authors describe some recent investigations undertaken in Japan with the object of finding an adjuvant for dried BCG vaccine which would make it possible for the vaccine to be stored at room temperature in tropical countries without suffering any serious loss of viability.The first series of experiments, carried out with sodium glutamate as adjuvant, was designed to determine the effect of the concentration of adjuvant, the concentration of bacilli, the pH of the bacterial suspension, and the method of freeze-drying on the preservability of the vaccine. The sucrose vaccine in current use in Japan served as a control. In the light of the results, the authors make certain suggestions as to the optimum conditions for freeze-drying, but they stress that their proposals are tentative and that further research on the subject is needed.In the second series of experiments the authors investigated the adjuvant properties of certain organic acids known to be involved in the metabolic reactions of the tubercle bacillus. Reasonably good results were obtained with alpha-ketoglutaric, malic, lactic, and citric acids, but none of these substances proved to be as satisfactory an adjuvant as sodium glutamate for storage at 37 degrees C. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/13489467/Further_studies_on_the_adjuvant_for_dried_BCG_vaccine_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/13489467/ DB - PRIME DP - Unbound Medicine ER -