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Effect of storage at 37 degrees C on allergenic potency of dried BCG vaccine.
Bull World Health Organ 1957; 17(2):275-86BW

Abstract

Experiments were carried out to determine the effect of storage at 37 degrees C on the allergenic potency for humans of dried BCG vaccine. From four lots of liquid vaccine, eight kinds of dried vaccine were prepared, four with 1% sodium glutamate and four with 1% sucrose as adjuvant. The eight vaccines were stored at 5 degrees C and at 37 degrees C for periods ranging from 1 month to 9 months, and were then used for the inoculation of primary-school children in Tokyo. These children were tuberculin-tested 1, 3 or 4 and, in a few cases, 12 months after vaccination, and the reactions were read approximately 48 hours after the tuberculin injection had been given.The tuberculin reactions induced by inoculation of the glutamate vaccines stored at 37 degrees C were, in all cases, appreciably stronger than those induced by the sucrose vaccines after storage at the same temperature for the same period. A slight decrease in the potency of the glutamate vaccines was observed after storage for 3 months at 37 degrees C, but storage for 1 month at this temperature did not appear to have any adverse effect on the potency.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

13489468

Citation

OBAYASHI, Y, et al. "Effect of Storage at 37 Degrees C On Allergenic Potency of Dried BCG Vaccine." Bulletin of the World Health Organization, vol. 17, no. 2, 1957, pp. 275-86.
OBAYASHI Y, CHO C, YOSHIOKA T, et al. Effect of storage at 37 degrees C on allergenic potency of dried BCG vaccine. Bull World Health Organ. 1957;17(2):275-86.
OBAYASHI, Y., CHO, C., YOSHIOKA, T., KAWASAKI, J., & SHIMAO, T. (1957). Effect of storage at 37 degrees C on allergenic potency of dried BCG vaccine. Bulletin of the World Health Organization, 17(2), pp. 275-86.
OBAYASHI Y, et al. Effect of Storage at 37 Degrees C On Allergenic Potency of Dried BCG Vaccine. Bull World Health Organ. 1957;17(2):275-86. PubMed PMID: 13489468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of storage at 37 degrees C on allergenic potency of dried BCG vaccine. AU - OBAYASHI,Y, AU - CHO,C, AU - YOSHIOKA,T, AU - KAWASAKI,J, AU - SHIMAO,T, PY - 1957/1/1/pubmed PY - 1957/1/1/medline PY - 1957/1/1/entrez KW - BCG VACCINATION SP - 275 EP - 86 JF - Bulletin of the World Health Organization JO - Bull. World Health Organ. VL - 17 IS - 2 N2 - Experiments were carried out to determine the effect of storage at 37 degrees C on the allergenic potency for humans of dried BCG vaccine. From four lots of liquid vaccine, eight kinds of dried vaccine were prepared, four with 1% sodium glutamate and four with 1% sucrose as adjuvant. The eight vaccines were stored at 5 degrees C and at 37 degrees C for periods ranging from 1 month to 9 months, and were then used for the inoculation of primary-school children in Tokyo. These children were tuberculin-tested 1, 3 or 4 and, in a few cases, 12 months after vaccination, and the reactions were read approximately 48 hours after the tuberculin injection had been given.The tuberculin reactions induced by inoculation of the glutamate vaccines stored at 37 degrees C were, in all cases, appreciably stronger than those induced by the sucrose vaccines after storage at the same temperature for the same period. A slight decrease in the potency of the glutamate vaccines was observed after storage for 3 months at 37 degrees C, but storage for 1 month at this temperature did not appear to have any adverse effect on the potency. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/13489468/Effect_of_storage_at_37_degrees_C_on_allergenic_potency_of_dried_BCG_vaccine_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/13489468/ DB - PRIME DP - Unbound Medicine ER -