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Further studies on BCG vaccine prepared by tween 80 method with particular reference to effect of freeze-drying.
Bull World Health Organ 1957; 17(2):295-306BW

Abstract

The immunizing potency of liquid BCG vaccine prepared by the Tween 80 method was compared with that of control vaccine prepared by the usual grinding method. The former vaccine revealed higher immunizing properties than the latter although its inoculation dose was only one-fifth as great.With sodium glutamate as adjuvant, freeze-drying was carried out on both vaccines. The viability of the resulting dried product was higher with the Tween 80 vaccine than with the control vaccine up to 12 months' preservation at 5 degrees C, and the allergenic potency of the dried Tween 80 vaccine stored at 5 degrees C was higher than that of the control vaccine. When the dried vaccine was preserved at 37 degrees C for a long period, the degree of decrease in viability was more marked in the Tween 80 vaccine than in the control vaccine.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

13489470

Citation

TAKANO, K, et al. "Further Studies On BCG Vaccine Prepared By Tween 80 Method With Particular Reference to Effect of Freeze-drying." Bulletin of the World Health Organization, vol. 17, no. 2, 1957, pp. 295-306.
TAKANO K, OBAYASHI Y, NOGUCHI T. Further studies on BCG vaccine prepared by tween 80 method with particular reference to effect of freeze-drying. Bull World Health Organ. 1957;17(2):295-306.
TAKANO, K., OBAYASHI, Y., & NOGUCHI, T. (1957). Further studies on BCG vaccine prepared by tween 80 method with particular reference to effect of freeze-drying. Bulletin of the World Health Organization, 17(2), pp. 295-306.
TAKANO K, OBAYASHI Y, NOGUCHI T. Further Studies On BCG Vaccine Prepared By Tween 80 Method With Particular Reference to Effect of Freeze-drying. Bull World Health Organ. 1957;17(2):295-306. PubMed PMID: 13489470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further studies on BCG vaccine prepared by tween 80 method with particular reference to effect of freeze-drying. AU - TAKANO,K, AU - OBAYASHI,Y, AU - NOGUCHI,T, PY - 1957/1/1/pubmed PY - 1957/1/1/medline PY - 1957/1/1/entrez KW - BCG VACCINATION SP - 295 EP - 306 JF - Bulletin of the World Health Organization JO - Bull. World Health Organ. VL - 17 IS - 2 N2 - The immunizing potency of liquid BCG vaccine prepared by the Tween 80 method was compared with that of control vaccine prepared by the usual grinding method. The former vaccine revealed higher immunizing properties than the latter although its inoculation dose was only one-fifth as great.With sodium glutamate as adjuvant, freeze-drying was carried out on both vaccines. The viability of the resulting dried product was higher with the Tween 80 vaccine than with the control vaccine up to 12 months' preservation at 5 degrees C, and the allergenic potency of the dried Tween 80 vaccine stored at 5 degrees C was higher than that of the control vaccine. When the dried vaccine was preserved at 37 degrees C for a long period, the degree of decrease in viability was more marked in the Tween 80 vaccine than in the control vaccine. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/13489470/Further_studies_on_BCG_vaccine_prepared_by_tween_80_method_with_particular_reference_to_effect_of_freeze_drying_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/13489470/ DB - PRIME DP - Unbound Medicine ER -