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Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil.
Lipids. 1992 Feb; 27(2):89-93.L

Abstract

Docosahexaenoic acid (22:6n-3) can be synthesized in the liver and/or brain from alpha-linolenic acid (18:3n-3) and is required in large amounts in structural membranes of developing brain and retina. The adequacy and efficacy of formulas containing 18:3n-3 and/or fish oil in providing 22:6n-3 for deposition was investigated in piglets fed formula from birth to 15 days. The test formulas contained high (HL) or low (LL) 18:3n-3 (3.9 or 0.7% of the total formula fatty acids, respectively), or low 18:3n-3 plus fish oil (LL+FO) to provide C20 and C22 n-3 polyunsaturated fatty acids (0.8% of total fatty acids). Fatty acid analyses of synaptic plasma membrane and retina ethanolamine phospholipids (EPL), which are especially enriched in 22:6n-3, were compared to those of 15-day-old piglets fed sow milk (SM). Feeding LL resulted in lower 22:6n-3 in synaptic plasma membrane. Fatty acid levels in HL and LL+FO piglets were equivalent to SM, with the exception of lower 22:5n-3 in the synaptic plasma membrane of LL+FO and in the retina of HL and LL+FO-fed piglets. Levels of 22:4n-6 were also lower in the retina of the LL+FO group. The results suggest formula 18:3n-3 is at least 24% as effective as C20 and C22 n-3 fatty acids as a source of membrane 22:6n-3. This study shows dietary 18:3n-3, as the only n-3 fatty acid, can support deposition of comparable percentage of 22:6n-3 to natural milk. Fish oil also supported tissue levels of 22:6n-3 similar to natural milk; however, lower 22:4n-6 may indicate possible inhibitory effects on n-6 metabolism.

Authors+Show Affiliations

Department of Human Nutrition, University of British Columbia, Vancouver, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1349717

Citation

Arbuckle, L D., and S M. Innis. "Docosahexaenoic Acid in Developing Brain and Retina of Piglets Fed High or Low Alpha-linolenate Formula With and Without Fish Oil." Lipids, vol. 27, no. 2, 1992, pp. 89-93.
Arbuckle LD, Innis SM. Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil. Lipids. 1992;27(2):89-93.
Arbuckle, L. D., & Innis, S. M. (1992). Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil. Lipids, 27(2), 89-93.
Arbuckle LD, Innis SM. Docosahexaenoic Acid in Developing Brain and Retina of Piglets Fed High or Low Alpha-linolenate Formula With and Without Fish Oil. Lipids. 1992;27(2):89-93. PubMed PMID: 1349717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil. AU - Arbuckle,L D, AU - Innis,S M, PY - 1992/2/1/pubmed PY - 1992/2/1/medline PY - 1992/2/1/entrez SP - 89 EP - 93 JF - Lipids JO - Lipids VL - 27 IS - 2 N2 - Docosahexaenoic acid (22:6n-3) can be synthesized in the liver and/or brain from alpha-linolenic acid (18:3n-3) and is required in large amounts in structural membranes of developing brain and retina. The adequacy and efficacy of formulas containing 18:3n-3 and/or fish oil in providing 22:6n-3 for deposition was investigated in piglets fed formula from birth to 15 days. The test formulas contained high (HL) or low (LL) 18:3n-3 (3.9 or 0.7% of the total formula fatty acids, respectively), or low 18:3n-3 plus fish oil (LL+FO) to provide C20 and C22 n-3 polyunsaturated fatty acids (0.8% of total fatty acids). Fatty acid analyses of synaptic plasma membrane and retina ethanolamine phospholipids (EPL), which are especially enriched in 22:6n-3, were compared to those of 15-day-old piglets fed sow milk (SM). Feeding LL resulted in lower 22:6n-3 in synaptic plasma membrane. Fatty acid levels in HL and LL+FO piglets were equivalent to SM, with the exception of lower 22:5n-3 in the synaptic plasma membrane of LL+FO and in the retina of HL and LL+FO-fed piglets. Levels of 22:4n-6 were also lower in the retina of the LL+FO group. The results suggest formula 18:3n-3 is at least 24% as effective as C20 and C22 n-3 fatty acids as a source of membrane 22:6n-3. This study shows dietary 18:3n-3, as the only n-3 fatty acid, can support deposition of comparable percentage of 22:6n-3 to natural milk. Fish oil also supported tissue levels of 22:6n-3 similar to natural milk; however, lower 22:4n-6 may indicate possible inhibitory effects on n-6 metabolism. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/1349717/Docosahexaenoic_acid_in_developing_brain_and_retina_of_piglets_fed_high_or_low_alpha_linolenate_formula_with_and_without_fish_oil_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0024-4201&date=1992&volume=27&issue=2&spage=89 DB - PRIME DP - Unbound Medicine ER -