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Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification.
Mov Disord. 1992; 7(2):117-24.MD

Abstract

Levodopa-induced dyskinesias (LID) in Parkinson's disease (PD) may be classified into three main categories: "On" dyskinesias, diphasic dyskinesias (DD), and "off" periods. The study of 168 parkinsonian patients showed that about half (n = 84) showed one pattern of LID only. A combination of two was present in 68, and 16 had the three presentation patterns. A fairly good correlation between type of dyskinesia and presentation pattern was established. Chorea, myoclonus, and dystonic movements occurred during the "on" period. Dystonic postures, particularly affecting the feet, were mainly present in the "off" period, but a few patients had a diphasic presentation. Repetitive stereotyped movements of the lower limbs always corresponded to DD. Acute pharmacological tests using dopamine agonists (subcutaneous apomorphine 3-8 mg; intravenous lisuride 0.1-0.15 mg) and dopamine antagonists (intravenous sulpiride 200-400 mg and intravenous chlorpromazine 25 mg) were performed in 40 patients. Dopamine agonists enhanced "on" dyskinesias and markedly reduced or abolished "off" period dystonia and DD. Dopamine antagonists reduced all types of LID but usually aggravated parkinsonism. These clinical and pharmacological results indicate that LID in PD are a heterogeneous phenomenon difficult to explain on the basis of a single pathophysiological mechanism.

Authors+Show Affiliations

Department of Neurology, Clinica Universitaria, University of Navarra, Pamplona-Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1350058

Citation

Luquin, M R., et al. "Levodopa-induced Dyskinesias in Parkinson's Disease: Clinical and Pharmacological Classification." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 7, no. 2, 1992, pp. 117-24.
Luquin MR, Scipioni O, Vaamonde J, et al. Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification. Mov Disord. 1992;7(2):117-24.
Luquin, M. R., Scipioni, O., Vaamonde, J., Gershanik, O., & Obeso, J. A. (1992). Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification. Movement Disorders : Official Journal of the Movement Disorder Society, 7(2), 117-24.
Luquin MR, et al. Levodopa-induced Dyskinesias in Parkinson's Disease: Clinical and Pharmacological Classification. Mov Disord. 1992;7(2):117-24. PubMed PMID: 1350058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification. AU - Luquin,M R, AU - Scipioni,O, AU - Vaamonde,J, AU - Gershanik,O, AU - Obeso,J A, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 117 EP - 24 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 7 IS - 2 N2 - Levodopa-induced dyskinesias (LID) in Parkinson's disease (PD) may be classified into three main categories: "On" dyskinesias, diphasic dyskinesias (DD), and "off" periods. The study of 168 parkinsonian patients showed that about half (n = 84) showed one pattern of LID only. A combination of two was present in 68, and 16 had the three presentation patterns. A fairly good correlation between type of dyskinesia and presentation pattern was established. Chorea, myoclonus, and dystonic movements occurred during the "on" period. Dystonic postures, particularly affecting the feet, were mainly present in the "off" period, but a few patients had a diphasic presentation. Repetitive stereotyped movements of the lower limbs always corresponded to DD. Acute pharmacological tests using dopamine agonists (subcutaneous apomorphine 3-8 mg; intravenous lisuride 0.1-0.15 mg) and dopamine antagonists (intravenous sulpiride 200-400 mg and intravenous chlorpromazine 25 mg) were performed in 40 patients. Dopamine agonists enhanced "on" dyskinesias and markedly reduced or abolished "off" period dystonia and DD. Dopamine antagonists reduced all types of LID but usually aggravated parkinsonism. These clinical and pharmacological results indicate that LID in PD are a heterogeneous phenomenon difficult to explain on the basis of a single pathophysiological mechanism. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/1350058/Levodopa_induced_dyskinesias_in_Parkinson's_disease:_clinical_and_pharmacological_classification_ L2 - https://doi.org/10.1002/mds.870070204 DB - PRIME DP - Unbound Medicine ER -