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Ethosuximide and tremor in Parkinson's disease: a pilot study.
Mov Disord. 1992; 7(2):132-6.MD

Abstract

Following the demonstration of an anti-tremor effect of ethosuximide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkey model, we have tested the effect of this drug in 10 patients with typical parkinsonian tremor. Six patients suffered from Parkinson's disease with prominent, relatively drug-resistant rest tremor. The other four patients had a drug-induced parkinsonian tremor due to neuroleptic agents taken for a psychiatric condition. Five of the six parkinsonian patients and three of the four psychiatric patients reported within a few days a marked and intolerable exacerbation of their tremor. One patient in each group was improved, and this improvement was verified in repeated examinations. Thus, for unknown reasons, the effect of ethosuximide was not as predicted by the monkey model. Among possible explanations is the fact that we had chosen patients with drug-resistant tremor.

Authors+Show Affiliations

Pourcher E
Unité de Neuropsychopharmacologie, Hôpital de l'Enfant-Jésus, Québec, Canada.
Gomez-Mancilla B
No affiliation info available
Bédard PJ
No affiliation info available

MeSH

AdultAgedAntipsychotic AgentsEthosuximideFemaleHumansMaleMiddle AgedNeurologic ExaminationParkinson DiseaseParkinson Disease, SecondaryPsychotic DisordersTremor

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

1350060

Citation

Pourcher, E, et al. "Ethosuximide and Tremor in Parkinson's Disease: a Pilot Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 7, no. 2, 1992, pp. 132-6.
Pourcher E, Gomez-Mancilla B, Bédard PJ. Ethosuximide and tremor in Parkinson's disease: a pilot study. Mov Disord. 1992;7(2):132-6.
Pourcher, E., Gomez-Mancilla, B., & Bédard, P. J. (1992). Ethosuximide and tremor in Parkinson's disease: a pilot study. Movement Disorders : Official Journal of the Movement Disorder Society, 7(2), 132-6.
Pourcher E, Gomez-Mancilla B, Bédard PJ. Ethosuximide and Tremor in Parkinson's Disease: a Pilot Study. Mov Disord. 1992;7(2):132-6. PubMed PMID: 1350060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethosuximide and tremor in Parkinson's disease: a pilot study. AU - Pourcher,E, AU - Gomez-Mancilla,B, AU - Bédard,P J, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 132 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 7 IS - 2 N2 - Following the demonstration of an anti-tremor effect of ethosuximide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkey model, we have tested the effect of this drug in 10 patients with typical parkinsonian tremor. Six patients suffered from Parkinson's disease with prominent, relatively drug-resistant rest tremor. The other four patients had a drug-induced parkinsonian tremor due to neuroleptic agents taken for a psychiatric condition. Five of the six parkinsonian patients and three of the four psychiatric patients reported within a few days a marked and intolerable exacerbation of their tremor. One patient in each group was improved, and this improvement was verified in repeated examinations. Thus, for unknown reasons, the effect of ethosuximide was not as predicted by the monkey model. Among possible explanations is the fact that we had chosen patients with drug-resistant tremor. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/1350060/Ethosuximide_and_tremor_in_Parkinson's_disease:_a_pilot_study_ DB - PRIME DP - Unbound Medicine ER -