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Glucagon mediates arginine-induced somatostatin secretion from isolated rat pancreatic islets.
Scand J Clin Lab Invest. 1992 Apr; 52(2):107-12.SJ

Abstract

Glucagon has been suggested to be a mediator of intra-islet paracrine effect of insulin and somatostatin during nutritive stimulation. The aim of this study was to reveal possible intra-islet interactions between insulin, somatostatin and glucagon in a batch stimulation model with isolated pancreatic islets. Such interactions may influence stimulus-secretion experiments in this experimental model. In our hands arginine stimulated somatostatin secretion only in the presence of insulin antiserum. Furthermore, arginine-induced glucagon secretion was greatly increased following addition of insulin antiserum. The addition of glucagon antiserum inhibited these effects of insulin antiserum on somatostatin secretion. In conclusion, glucagon apparently represents the central mediator of arginine effects on somatostatin secretion in isolated rat pancreatic islets in batch stimulation experiments.

Authors+Show Affiliations

Vonen B
Department of Medicine, University Hospital of Tromsø, Norway.
Florholmen J
No affiliation info available
Malm D
No affiliation info available
Torjessen P
No affiliation info available
Burhol PG
No affiliation info available

MeSH

AnimalsArginineGlucagonImmune SeraIn Vitro TechniquesInsulinInsulin SecretionIslets of LangerhansRatsSomatostatin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1350374

Citation

Vonen, B, et al. "Glucagon Mediates Arginine-induced Somatostatin Secretion From Isolated Rat Pancreatic Islets." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 52, no. 2, 1992, pp. 107-12.
Vonen B, Florholmen J, Malm D, et al. Glucagon mediates arginine-induced somatostatin secretion from isolated rat pancreatic islets. Scand J Clin Lab Invest. 1992;52(2):107-12.
Vonen, B., Florholmen, J., Malm, D., Torjessen, P., & Burhol, P. G. (1992). Glucagon mediates arginine-induced somatostatin secretion from isolated rat pancreatic islets. Scandinavian Journal of Clinical and Laboratory Investigation, 52(2), 107-12.
Vonen B, et al. Glucagon Mediates Arginine-induced Somatostatin Secretion From Isolated Rat Pancreatic Islets. Scand J Clin Lab Invest. 1992;52(2):107-12. PubMed PMID: 1350374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucagon mediates arginine-induced somatostatin secretion from isolated rat pancreatic islets. AU - Vonen,B, AU - Florholmen,J, AU - Malm,D, AU - Torjessen,P, AU - Burhol,P G, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 107 EP - 12 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 52 IS - 2 N2 - Glucagon has been suggested to be a mediator of intra-islet paracrine effect of insulin and somatostatin during nutritive stimulation. The aim of this study was to reveal possible intra-islet interactions between insulin, somatostatin and glucagon in a batch stimulation model with isolated pancreatic islets. Such interactions may influence stimulus-secretion experiments in this experimental model. In our hands arginine stimulated somatostatin secretion only in the presence of insulin antiserum. Furthermore, arginine-induced glucagon secretion was greatly increased following addition of insulin antiserum. The addition of glucagon antiserum inhibited these effects of insulin antiserum on somatostatin secretion. In conclusion, glucagon apparently represents the central mediator of arginine effects on somatostatin secretion in isolated rat pancreatic islets in batch stimulation experiments. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/1350374/Glucagon_mediates_arginine_induced_somatostatin_secretion_from_isolated_rat_pancreatic_islets_ DB - PRIME DP - Unbound Medicine ER -