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Treatment of tardive dyskinesia with vitamin E.
Am J Psychiatry 1992; 149(6):773-7AJ

Abstract

OBJECTIVE

Vitamin E (alpha-tocopherol), a free-radical scavenger, has been reported to improve symptoms of tardive dyskinesia. The authors attempted to replicate this finding under more controlled conditions in a larger study group.

METHOD

Fifteen inpatients and six outpatients with tardive dyskinesia received up to 1600 IU/day of vitamin E for 6 weeks in a double-blind, placebo-controlled crossover study. Abnormal Involuntary Movement Scale (AIMS) examinations of these patients were videotaped and rated independently by two trained raters. Levels of neuroleptic medication and vitamin E were measured during both treatment periods. Eighteen patients who demonstrated high blood levels of vitamin E were included in the data analysis.

RESULTS

Vitamin E levels were significantly higher while the patients were receiving vitamin E than while they were receiving placebo. For all 18 patients, there were no significant differences between AIMS scores after receiving vitamin E and AIMS scores after receiving placebo. In agreement with previous studies, however, the nine patients who had had tardive dyskinesia for 5 years or less had significantly lower AIMS scores after receiving vitamin E than after receiving placebo. There were no changes in neuroleptic levels during vitamin E treatment.

CONCLUSIONS

Vitamin E had a minor beneficial effect on tardive dyskinesia ratings in a selected group of patients who had had tardive dyskinesia for 5 years or less. This effect was not due to an increase in blood levels of neuroleptic medications.

Authors+Show Affiliations

Neuropsychiatry Branch, NIMH, Washington, D.C. 20032.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1350428

Citation

Egan, M F., et al. "Treatment of Tardive Dyskinesia With Vitamin E." The American Journal of Psychiatry, vol. 149, no. 6, 1992, pp. 773-7.
Egan MF, Hyde TM, Albers GW, et al. Treatment of tardive dyskinesia with vitamin E. Am J Psychiatry. 1992;149(6):773-7.
Egan, M. F., Hyde, T. M., Albers, G. W., Elkashef, A., Alexander, R. C., Reeve, A., ... Wyatt, R. J. (1992). Treatment of tardive dyskinesia with vitamin E. The American Journal of Psychiatry, 149(6), pp. 773-7.
Egan MF, et al. Treatment of Tardive Dyskinesia With Vitamin E. Am J Psychiatry. 1992;149(6):773-7. PubMed PMID: 1350428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of tardive dyskinesia with vitamin E. AU - Egan,M F, AU - Hyde,T M, AU - Albers,G W, AU - Elkashef,A, AU - Alexander,R C, AU - Reeve,A, AU - Blum,A, AU - Saenz,R E, AU - Wyatt,R J, PY - 1992/6/1/pubmed PY - 1992/6/1/medline PY - 1992/6/1/entrez SP - 773 EP - 7 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 149 IS - 6 N2 - OBJECTIVE: Vitamin E (alpha-tocopherol), a free-radical scavenger, has been reported to improve symptoms of tardive dyskinesia. The authors attempted to replicate this finding under more controlled conditions in a larger study group. METHOD: Fifteen inpatients and six outpatients with tardive dyskinesia received up to 1600 IU/day of vitamin E for 6 weeks in a double-blind, placebo-controlled crossover study. Abnormal Involuntary Movement Scale (AIMS) examinations of these patients were videotaped and rated independently by two trained raters. Levels of neuroleptic medication and vitamin E were measured during both treatment periods. Eighteen patients who demonstrated high blood levels of vitamin E were included in the data analysis. RESULTS: Vitamin E levels were significantly higher while the patients were receiving vitamin E than while they were receiving placebo. For all 18 patients, there were no significant differences between AIMS scores after receiving vitamin E and AIMS scores after receiving placebo. In agreement with previous studies, however, the nine patients who had had tardive dyskinesia for 5 years or less had significantly lower AIMS scores after receiving vitamin E than after receiving placebo. There were no changes in neuroleptic levels during vitamin E treatment. CONCLUSIONS: Vitamin E had a minor beneficial effect on tardive dyskinesia ratings in a selected group of patients who had had tardive dyskinesia for 5 years or less. This effect was not due to an increase in blood levels of neuroleptic medications. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/1350428/Treatment_of_tardive_dyskinesia_with_vitamin_E_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.149.6.773?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -