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Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (II). Antagonistic effect of epinastine on chemical mediators, mainly antihistaminic and anti-PAF effects.
Immunopharmacol Immunotoxicol. 1992; 14(1-2):207-18.II

Abstract

Anti-histamine and anti-PAF effects of epinastine were tested in rats, guinea pigs and rabbits. Epinastine showed a potent histamine H1-blocking effect, but the potency was slightly less than that of ketotifen in histamine-induced contraction of guinea pig ileum and histamine-induced cutaneous reactions in rats. In histamine-induced dye leakage into the nasal cavity tested in rats, the drug was slightly more potent than ketotifen and azelastine. Epinastine as well as ketotifen suppressed rabbit platelet aggregation induced by PAF at higher concentrations compared with WEB 2086, a specific PAF-antagonist. In the bronchospasm induced by PAF in guinea pigs, epinastine was more effective than ketotifen in inhibiting the bronchoconstriction, while it showed no remarkable effect on the hypotension induced by PAF. Epinastine caused a potent antagonistic effect on LTC4-induced contraction of isolated guinea pig trachea. In conclusion, the potent anti-histamine, anti-PAF and anti-LT effects of epinastine may significantly contribute to its antiallergic activity.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1350791

Citation

Kamei, C, et al. "Antiallergic Effect of Epinastine (WAL 801 CL) On Immediate Hypersensitivity Reactions: (II). Antagonistic Effect of Epinastine On Chemical Mediators, Mainly Antihistaminic and anti-PAF Effects." Immunopharmacology and Immunotoxicology, vol. 14, no. 1-2, 1992, pp. 207-18.
Kamei C, Mio M, Kitazumi K, et al. Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (II). Antagonistic effect of epinastine on chemical mediators, mainly antihistaminic and anti-PAF effects. Immunopharmacol Immunotoxicol. 1992;14(1-2):207-18.
Kamei, C., Mio, M., Kitazumi, K., Tsujimoto, S., Yoshida, T., Adachi, Y., & Tasaka, K. (1992). Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (II). Antagonistic effect of epinastine on chemical mediators, mainly antihistaminic and anti-PAF effects. Immunopharmacology and Immunotoxicology, 14(1-2), 207-18.
Kamei C, et al. Antiallergic Effect of Epinastine (WAL 801 CL) On Immediate Hypersensitivity Reactions: (II). Antagonistic Effect of Epinastine On Chemical Mediators, Mainly Antihistaminic and anti-PAF Effects. Immunopharmacol Immunotoxicol. 1992;14(1-2):207-18. PubMed PMID: 1350791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (II). Antagonistic effect of epinastine on chemical mediators, mainly antihistaminic and anti-PAF effects. AU - Kamei,C, AU - Mio,M, AU - Kitazumi,K, AU - Tsujimoto,S, AU - Yoshida,T, AU - Adachi,Y, AU - Tasaka,K, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 207 EP - 18 JF - Immunopharmacology and immunotoxicology JO - Immunopharmacol Immunotoxicol VL - 14 IS - 1-2 N2 - Anti-histamine and anti-PAF effects of epinastine were tested in rats, guinea pigs and rabbits. Epinastine showed a potent histamine H1-blocking effect, but the potency was slightly less than that of ketotifen in histamine-induced contraction of guinea pig ileum and histamine-induced cutaneous reactions in rats. In histamine-induced dye leakage into the nasal cavity tested in rats, the drug was slightly more potent than ketotifen and azelastine. Epinastine as well as ketotifen suppressed rabbit platelet aggregation induced by PAF at higher concentrations compared with WEB 2086, a specific PAF-antagonist. In the bronchospasm induced by PAF in guinea pigs, epinastine was more effective than ketotifen in inhibiting the bronchoconstriction, while it showed no remarkable effect on the hypotension induced by PAF. Epinastine caused a potent antagonistic effect on LTC4-induced contraction of isolated guinea pig trachea. In conclusion, the potent anti-histamine, anti-PAF and anti-LT effects of epinastine may significantly contribute to its antiallergic activity. SN - 0892-3973 UR - https://www.unboundmedicine.com/medline/citation/1350791/Antiallergic_effect_of_epinastine__WAL_801_CL__on_immediate_hypersensitivity_reactions:__II___Antagonistic_effect_of_epinastine_on_chemical_mediators_mainly_antihistaminic_and_anti_PAF_effects_ L2 - https://www.tandfonline.com/doi/full/10.3109/08923979209009220 DB - PRIME DP - Unbound Medicine ER -