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Somatostatin receptor elevation in rat striatum after diisopropylfluorophosphate administration.
Brain Res Bull. 1992 Apr; 28(4):513-8.BR

Abstract

The acute and chronic administration of diisopropylfluorophosphate (DFP), an inhibitor of acetylcholinesterase or of atropine, a blocker of muscarinic cholinergic receptors, did not affect somatostatin-like immunoreactivity (SLI) content in the striatum of rats. Acute and chronic DFP administration increased the number of specific 125I-Tyr11-somatostatin (125I-Tyr11-SS) receptors in cells dissociated from the striatum without changing the affinity constant. Although the increase could be blocked by pretreatment with atropine, it was not due to a direct effect by DFP on somatostatin (SS) receptors, because no rise in 125I-Tyr11-SS binding was produced by high concentrations of DFP (10(-5) M) when added in vitro. The acute administration of atropine alone had no observable effect on the number of SS receptors. However, repeated atropine administration produced a significant decrease in the 125I-Tyr11-SS binding in cells dissociated from the striatum, although the affinity constant was unchanged. The results suggest that interactions between somatostatinergic and cholinergic receptors may be of importance in the rat striatum.

Authors+Show Affiliations

Alvaro I
Department of Biochemistry and Molecular Biology, Medical School, University of Alcala, Madrid, Spain.
Arilla E
No affiliation info available

MeSH

AnimalsAtropineCorpus StriatumIsoflurophateRadioimmunoassayRatsRats, Inbred StrainsReceptors, NeurotransmitterReceptors, SomatostatinSomatostatin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1352176

Citation

Alvaro, I, and E Arilla. "Somatostatin Receptor Elevation in Rat Striatum After Diisopropylfluorophosphate Administration." Brain Research Bulletin, vol. 28, no. 4, 1992, pp. 513-8.
Alvaro I, Arilla E. Somatostatin receptor elevation in rat striatum after diisopropylfluorophosphate administration. Brain Res Bull. 1992;28(4):513-8.
Alvaro, I., & Arilla, E. (1992). Somatostatin receptor elevation in rat striatum after diisopropylfluorophosphate administration. Brain Research Bulletin, 28(4), 513-8.
Alvaro I, Arilla E. Somatostatin Receptor Elevation in Rat Striatum After Diisopropylfluorophosphate Administration. Brain Res Bull. 1992;28(4):513-8. PubMed PMID: 1352176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatostatin receptor elevation in rat striatum after diisopropylfluorophosphate administration. AU - Alvaro,I, AU - Arilla,E, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 513 EP - 8 JF - Brain research bulletin JO - Brain Res Bull VL - 28 IS - 4 N2 - The acute and chronic administration of diisopropylfluorophosphate (DFP), an inhibitor of acetylcholinesterase or of atropine, a blocker of muscarinic cholinergic receptors, did not affect somatostatin-like immunoreactivity (SLI) content in the striatum of rats. Acute and chronic DFP administration increased the number of specific 125I-Tyr11-somatostatin (125I-Tyr11-SS) receptors in cells dissociated from the striatum without changing the affinity constant. Although the increase could be blocked by pretreatment with atropine, it was not due to a direct effect by DFP on somatostatin (SS) receptors, because no rise in 125I-Tyr11-SS binding was produced by high concentrations of DFP (10(-5) M) when added in vitro. The acute administration of atropine alone had no observable effect on the number of SS receptors. However, repeated atropine administration produced a significant decrease in the 125I-Tyr11-SS binding in cells dissociated from the striatum, although the affinity constant was unchanged. The results suggest that interactions between somatostatinergic and cholinergic receptors may be of importance in the rat striatum. SN - 0361-9230 UR - https://www.unboundmedicine.com/medline/citation/1352176/Somatostatin_receptor_elevation_in_rat_striatum_after_diisopropylfluorophosphate_administration_ DB - PRIME DP - Unbound Medicine ER -