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Convulsive seizures in schizophrenic patients induced by zotepine administration.
Jpn J Psychiatry Neurol. 1992 Mar; 46(1):161-7.JJ

Abstract

One hundred twenty-nine schizophrenic inpatients who were administered zotepine were studied to see if they had zotepine-induced convulsive seizures. Twenty-two patients had grand mal seizures during the administration periods. The incidence of the seizure was 17.1% and was higher than that in previous reports. The average duration of zotepine administration before the seizure was 48.3 days. The incidence of the seizure was closely related to the daily dosage of zotepine, but there was no significant correlation between the daily dosage of zotepine and the duration of administration before the onset of the seizure. The patients who received a combined administration with the higher dose of zotepine and other phenothiazines were revealed to be more likely to have the seizure. In addition, young patients and patients with a past history of head injuries showed a high incidence of the seizure with the administration of zotepine.

Authors+Show Affiliations

Department of Psychiatry, University of Tsukuba, Ibaraki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1353125

Citation

Hori, M, et al. "Convulsive Seizures in Schizophrenic Patients Induced By Zotepine Administration." The Japanese Journal of Psychiatry and Neurology, vol. 46, no. 1, 1992, pp. 161-7.
Hori M, Suzuki T, Sasaki M, et al. Convulsive seizures in schizophrenic patients induced by zotepine administration. Jpn J Psychiatry Neurol. 1992;46(1):161-7.
Hori, M., Suzuki, T., Sasaki, M., Shiraishi, H., & Koizumi, J. (1992). Convulsive seizures in schizophrenic patients induced by zotepine administration. The Japanese Journal of Psychiatry and Neurology, 46(1), 161-7.
Hori M, et al. Convulsive Seizures in Schizophrenic Patients Induced By Zotepine Administration. Jpn J Psychiatry Neurol. 1992;46(1):161-7. PubMed PMID: 1353125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Convulsive seizures in schizophrenic patients induced by zotepine administration. AU - Hori,M, AU - Suzuki,T, AU - Sasaki,M, AU - Shiraishi,H, AU - Koizumi,J, PY - 1992/3/1/pubmed PY - 1992/3/1/medline PY - 1992/3/1/entrez SP - 161 EP - 7 JF - The Japanese journal of psychiatry and neurology JO - Jpn J Psychiatry Neurol VL - 46 IS - 1 N2 - One hundred twenty-nine schizophrenic inpatients who were administered zotepine were studied to see if they had zotepine-induced convulsive seizures. Twenty-two patients had grand mal seizures during the administration periods. The incidence of the seizure was 17.1% and was higher than that in previous reports. The average duration of zotepine administration before the seizure was 48.3 days. The incidence of the seizure was closely related to the daily dosage of zotepine, but there was no significant correlation between the daily dosage of zotepine and the duration of administration before the onset of the seizure. The patients who received a combined administration with the higher dose of zotepine and other phenothiazines were revealed to be more likely to have the seizure. In addition, young patients and patients with a past history of head injuries showed a high incidence of the seizure with the administration of zotepine. SN - 0912-2036 UR - https://www.unboundmedicine.com/medline/citation/1353125/Convulsive_seizures_in_schizophrenic_patients_induced_by_zotepine_administration_ L2 - https://www.diseaseinfosearch.org/result/6489 DB - PRIME DP - Unbound Medicine ER -