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Effects of acute and chronic desipramine treatment on somatostatin receptors in brain.
Psychopharmacology (Berl). 1992; 108(3):363-6.P

Abstract

The effects of acute (5 mg/kg, IP twice daily for 2 days) and chronic (5 mg/kg IP twice daily for 21 days) administration of desipramine (DMI) on [125I]-Tyr11-somatostatin binding sites in brain were examined. There was no change in [125I]Tyr11-somatostatin binding in membranes prepared from the frontal cortex, striatum, and hippocampus of rats acutely or chronically treated with DMI as compared to non treated animals. [125I]Tyr11-somatostatin binding was increased in membranes prepared from the rat nucleus accumbens only after chronic DMI administration. Scatchard analysis of the binding data from the nucleus accumbens showed that [125I]Tyr11-somatostatin labels a single population of somatostatin binding sites with an affinity constant, Kd, of 1.8 +/- 0.60 nM and a Bmax of 330 +/- 90 fmol/mg protein. Chronic treatment with DMI increased the Bmax (500 +/- 140 fmol/mg protein) but had no effect on the Kd. This finding shows a regional effect of DMI on [125I]Tyr11-somatostatin binding sites in rat brain and suggests that somatostatin may play a role in the pathophysiology of depression.

Authors+Show Affiliations

Gheorvassaki EG
Department of Basic Sciences, School of Health Sciences, University of Crete, Heraklion, Greece.
Thermos K
No affiliation info available
Liapakis G
No affiliation info available
Spyraki C
No affiliation info available

MeSH

AnimalsBrain ChemistryDesipramineIodine RadioisotopesKineticsMaleMembranesNucleus AccumbensRatsRats, Inbred StrainsReceptors, NeurotransmitterReceptors, SomatostatinSomatostatin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1355925

Citation

Gheorvassaki, E G., et al. "Effects of Acute and Chronic Desipramine Treatment On Somatostatin Receptors in Brain." Psychopharmacology, vol. 108, no. 3, 1992, pp. 363-6.
Gheorvassaki EG, Thermos K, Liapakis G, et al. Effects of acute and chronic desipramine treatment on somatostatin receptors in brain. Psychopharmacology (Berl). 1992;108(3):363-6.
Gheorvassaki, E. G., Thermos, K., Liapakis, G., & Spyraki, C. (1992). Effects of acute and chronic desipramine treatment on somatostatin receptors in brain. Psychopharmacology, 108(3), 363-6.
Gheorvassaki EG, et al. Effects of Acute and Chronic Desipramine Treatment On Somatostatin Receptors in Brain. Psychopharmacology (Berl). 1992;108(3):363-6. PubMed PMID: 1355925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acute and chronic desipramine treatment on somatostatin receptors in brain. AU - Gheorvassaki,E G, AU - Thermos,K, AU - Liapakis,G, AU - Spyraki,C, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 363 EP - 6 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 108 IS - 3 N2 - The effects of acute (5 mg/kg, IP twice daily for 2 days) and chronic (5 mg/kg IP twice daily for 21 days) administration of desipramine (DMI) on [125I]-Tyr11-somatostatin binding sites in brain were examined. There was no change in [125I]Tyr11-somatostatin binding in membranes prepared from the frontal cortex, striatum, and hippocampus of rats acutely or chronically treated with DMI as compared to non treated animals. [125I]Tyr11-somatostatin binding was increased in membranes prepared from the rat nucleus accumbens only after chronic DMI administration. Scatchard analysis of the binding data from the nucleus accumbens showed that [125I]Tyr11-somatostatin labels a single population of somatostatin binding sites with an affinity constant, Kd, of 1.8 +/- 0.60 nM and a Bmax of 330 +/- 90 fmol/mg protein. Chronic treatment with DMI increased the Bmax (500 +/- 140 fmol/mg protein) but had no effect on the Kd. This finding shows a regional effect of DMI on [125I]Tyr11-somatostatin binding sites in rat brain and suggests that somatostatin may play a role in the pathophysiology of depression. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/1355925/Effects_of_acute_and_chronic_desipramine_treatment_on_somatostatin_receptors_in_brain_ DB - PRIME DP - Unbound Medicine ER -