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Abnormal expression of Ki-67 antigen in hair follicle of alopecia areata.
Acta Derm Venereol. 1992; 72(3):161-4.AD

Abstract

The monoclonal antibody Ki-67 was used to determine the numbers of cycling cells in hair follicles both in alopecia areata and in normal scalp skin. Pronounced nuclear staining was limited to the area below the critical line of Auber and the exterior part of the outer root sheath. In alopecia areata there is reduced nuclear Ki-67 binding in the bulb of anagen hair follicles. These findings indicate that inhibition of keratinocyte proliferation might be a pathogenetic mechanism in alopecia areata.

Authors+Show Affiliations

van Baar HM
Department of Dermatology, University Nijmegen, The Netherlands.
Perret CM
No affiliation info available
van Vlijmen IM
No affiliation info available
van de Kerkhof PC
No affiliation info available
Happle R
No affiliation info available
Schalkwijk J
No affiliation info available

MeSH

Alopecia AreataAntibodies, MonoclonalAntigensCell DivisionCell NucleusHairHumansKeratinocytes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1357847

Citation

van Baar, H M., et al. "Abnormal Expression of Ki-67 Antigen in Hair Follicle of Alopecia Areata." Acta Dermato-venereologica, vol. 72, no. 3, 1992, pp. 161-4.
van Baar HM, Perret CM, van Vlijmen IM, et al. Abnormal expression of Ki-67 antigen in hair follicle of alopecia areata. Acta Derm Venereol. 1992;72(3):161-4.
van Baar, H. M., Perret, C. M., van Vlijmen, I. M., van de Kerkhof, P. C., Happle, R., & Schalkwijk, J. (1992). Abnormal expression of Ki-67 antigen in hair follicle of alopecia areata. Acta Dermato-venereologica, 72(3), 161-4.
van Baar HM, et al. Abnormal Expression of Ki-67 Antigen in Hair Follicle of Alopecia Areata. Acta Derm Venereol. 1992;72(3):161-4. PubMed PMID: 1357847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal expression of Ki-67 antigen in hair follicle of alopecia areata. AU - van Baar,H M, AU - Perret,C M, AU - van Vlijmen,I M, AU - van de Kerkhof,P C, AU - Happle,R, AU - Schalkwijk,J, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 161 EP - 4 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 72 IS - 3 N2 - The monoclonal antibody Ki-67 was used to determine the numbers of cycling cells in hair follicles both in alopecia areata and in normal scalp skin. Pronounced nuclear staining was limited to the area below the critical line of Auber and the exterior part of the outer root sheath. In alopecia areata there is reduced nuclear Ki-67 binding in the bulb of anagen hair follicles. These findings indicate that inhibition of keratinocyte proliferation might be a pathogenetic mechanism in alopecia areata. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/1357847/Abnormal_expression_of_Ki_67_antigen_in_hair_follicle_of_alopecia_areata_ DB - PRIME DP - Unbound Medicine ER -