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[Genetic alterations in the genesis and development of ovarian cancer].
Gan To Kagaku Ryoho 1992; 19(12):1971-6GT

Abstract

Genetic alterations of various cancers have been clarified by recent development of molecular biology. Multiple genetic alterations occur through the development of cancer. Both activation of proto-oncogenes and inactivation of tumor suppressor genes are important for the development of cancer. Alterations of oncogenes such as K-ras, c-erbB-2/HER-2/neu and c-myc, and those of tumor suppressor genes such as p53, RB and DCC have been reported in ovarian cancer. Allelic losses of the specific chromosomes, which suggest the existence of tumor suppressor genes on those chromosomes, also have been reported in ovarian cancer. Further studies on genetic alterations of ovarian cancer will clarify the mechanisms for the development of ovarian cancer and also will develop new methods for prevention, diagnosis and treatment in clinical.

Authors+Show Affiliations

Dept. of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

1358031

Citation

Okamoto, A, et al. "[Genetic Alterations in the Genesis and Development of Ovarian Cancer]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 19, no. 12, 1992, pp. 1971-6.
Okamoto A, Yokoyama S, Terashima Y. [Genetic alterations in the genesis and development of ovarian cancer]. Gan To Kagaku Ryoho. 1992;19(12):1971-6.
Okamoto, A., Yokoyama, S., & Terashima, Y. (1992). [Genetic alterations in the genesis and development of ovarian cancer]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 19(12), pp. 1971-6.
Okamoto A, Yokoyama S, Terashima Y. [Genetic Alterations in the Genesis and Development of Ovarian Cancer]. Gan To Kagaku Ryoho. 1992;19(12):1971-6. PubMed PMID: 1358031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Genetic alterations in the genesis and development of ovarian cancer]. AU - Okamoto,A, AU - Yokoyama,S, AU - Terashima,Y, PY - 1992/10/1/pubmed PY - 1992/10/1/medline PY - 1992/10/1/entrez SP - 1971 EP - 6 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 19 IS - 12 N2 - Genetic alterations of various cancers have been clarified by recent development of molecular biology. Multiple genetic alterations occur through the development of cancer. Both activation of proto-oncogenes and inactivation of tumor suppressor genes are important for the development of cancer. Alterations of oncogenes such as K-ras, c-erbB-2/HER-2/neu and c-myc, and those of tumor suppressor genes such as p53, RB and DCC have been reported in ovarian cancer. Allelic losses of the specific chromosomes, which suggest the existence of tumor suppressor genes on those chromosomes, also have been reported in ovarian cancer. Further studies on genetic alterations of ovarian cancer will clarify the mechanisms for the development of ovarian cancer and also will develop new methods for prevention, diagnosis and treatment in clinical. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/1358031/[Genetic_alterations_in_the_genesis_and_development_of_ovarian_cancer]_ L2 - http://www.diseaseinfosearch.org/result/5504 DB - PRIME DP - Unbound Medicine ER -