Tags

Type your tag names separated by a space and hit enter

Hepatitis C virus and porphyria cutanea tarda: evidence of a strong association.

Abstract

Porphyria cutanea tarda in human beings is believed to be due to reduced hepatic uroporphyrinogen decarboxylase activity. However, extrinsic factors such as alcohol abuse and drug intake are required for clinical manifestation of the disease. In addition to typical cutaneous lesions, patients with porphyria cutanea tarda usually have chronic liver disease and moderate iron overload. Of 74 Italian patients with porphyria cutanea tarda, hepatitis C virus antibodies were detected in 76% by enzyme-linked immunoassay and in 82% by recombinant immunoblot assay. Viral genome, studied with nested polymerase chain reaction, was found in the sera of 49 subjects--47 positive and 2 indeterminate on recombinant immunoblot assay. Five percent of the patients were HBsAg-positive, and about 40% had had past hepatitis B contacts. Alcohol abuse was present in 38%. Liver biopsies performed in 42 patients showed chronic persistent hepatitis in 7 patients, chronic active hepatitis in 22 patients, fibrosis in three patients and cirrhosis in 10 patients. Hepatitis C virus antibody was detected in 100% of patients with chronic active hepatitis and in about 80% of all other groups. Alcohol abuse was more frequent in patients with cirrhosis (80%) than in the other groups. In Italian patients with porphyria cutanea tarda, the prevalence of hepatitis C virus infection was very high, comparable to that in non-A, non-B hepatitis and high-risk patient groups. Hepatitis C virus is probably the main pathogenetic factor of the liver disease of patients with porphyria cutanea tarda.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Internal Medicine and Medical Physiopathology, University of Milan, Italy.

    , , , , , , , ,

    Source

    Hepatology (Baltimore, Md.) 16:6 1992 Dec pg 1322-6

    MeSH

    Alcoholism
    Base Sequence
    Female
    Genome, Viral
    Hepacivirus
    Hepatitis B Core Antigens
    Hepatitis B Surface Antigens
    Hepatitis C
    Humans
    Liver
    Liver Diseases
    Male
    Middle Aged
    Molecular Sequence Data
    Oligodeoxyribonucleotides
    Polymerase Chain Reaction
    Porphyria Cutanea Tarda
    Prevalence
    RNA, Viral

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    1359994

    Citation

    Fargion, S, et al. "Hepatitis C Virus and Porphyria Cutanea Tarda: Evidence of a Strong Association." Hepatology (Baltimore, Md.), vol. 16, no. 6, 1992, pp. 1322-6.
    Fargion S, Piperno A, Cappellini MD, et al. Hepatitis C virus and porphyria cutanea tarda: evidence of a strong association. Hepatology. 1992;16(6):1322-6.
    Fargion, S., Piperno, A., Cappellini, M. D., Sampietro, M., Fracanzani, A. L., Romano, R., ... Fiorelli, G. (1992). Hepatitis C virus and porphyria cutanea tarda: evidence of a strong association. Hepatology (Baltimore, Md.), 16(6), pp. 1322-6.
    Fargion S, et al. Hepatitis C Virus and Porphyria Cutanea Tarda: Evidence of a Strong Association. Hepatology. 1992;16(6):1322-6. PubMed PMID: 1359994.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hepatitis C virus and porphyria cutanea tarda: evidence of a strong association. AU - Fargion,S, AU - Piperno,A, AU - Cappellini,M D, AU - Sampietro,M, AU - Fracanzani,A L, AU - Romano,R, AU - Caldarelli,R, AU - Marcelli,R, AU - Vecchi,L, AU - Fiorelli,G, PY - 1992/12/1/pubmed PY - 1992/12/1/medline PY - 1992/12/1/entrez SP - 1322 EP - 6 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 16 IS - 6 N2 - Porphyria cutanea tarda in human beings is believed to be due to reduced hepatic uroporphyrinogen decarboxylase activity. However, extrinsic factors such as alcohol abuse and drug intake are required for clinical manifestation of the disease. In addition to typical cutaneous lesions, patients with porphyria cutanea tarda usually have chronic liver disease and moderate iron overload. Of 74 Italian patients with porphyria cutanea tarda, hepatitis C virus antibodies were detected in 76% by enzyme-linked immunoassay and in 82% by recombinant immunoblot assay. Viral genome, studied with nested polymerase chain reaction, was found in the sera of 49 subjects--47 positive and 2 indeterminate on recombinant immunoblot assay. Five percent of the patients were HBsAg-positive, and about 40% had had past hepatitis B contacts. Alcohol abuse was present in 38%. Liver biopsies performed in 42 patients showed chronic persistent hepatitis in 7 patients, chronic active hepatitis in 22 patients, fibrosis in three patients and cirrhosis in 10 patients. Hepatitis C virus antibody was detected in 100% of patients with chronic active hepatitis and in about 80% of all other groups. Alcohol abuse was more frequent in patients with cirrhosis (80%) than in the other groups. In Italian patients with porphyria cutanea tarda, the prevalence of hepatitis C virus infection was very high, comparable to that in non-A, non-B hepatitis and high-risk patient groups. Hepatitis C virus is probably the main pathogenetic factor of the liver disease of patients with porphyria cutanea tarda. SN - 0270-9139 UR - https://www.unboundmedicine.com/medline/citation/1359994/Hepatitis_C_virus_and_porphyria_cutanea_tarda:_evidence_of_a_strong_association_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0270-9139&date=1992&volume=16&issue=6&spage=1322 DB - PRIME DP - Unbound Medicine ER -