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Molecular genetic mapping of the multiple endocrine neoplasia type 1 locus.
Henry Ford Hosp Med J. 1992; 40(3-4):162-6.HF

Abstract

Familial multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant disorder characterized by the combined occurrence of tumors of the parathyroid glands, the endocrine pancreas, and the pituitary gland. MEN 1 tumors have previously been shown to be associated with the loss of alleles on chromosome 11, and deletion mapping studies together with family linkage studies have localized the MEN 1 gene to 11q13. A detailed genetic map around the MEN 1 locus is required to facilitate further characterization and cloning of the gene (MEN1). We have characterized a panel of seven rodent-human somatic cell hybrids which contain fragments of human chromosome 11 with breakpoints in the pericentromeric region by using eight DNA sequences (D11S149, PGA, PYGM, D11S97, INT2, D11S37, D11S533, and D11S147) to define the region containing MEN1. This will facilitate the rapid localization of additional DNA sequences in this region. In addition, we have used a highly polymorphic repetitive degenerate hexanucleotide sequence, designated D11S533, for segregation studies in one family with MEN 1. These molecular genetic approaches will help to define a precise 1 to 2 centiMorgan map around MEN1.

Authors+Show Affiliations

Division of Molecular Medicine, MRC Clinical Research Centre, Harrow, Middlesex, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1362397

Citation

Pang, J T., et al. "Molecular Genetic Mapping of the Multiple Endocrine Neoplasia Type 1 Locus." Henry Ford Hospital Medical Journal, vol. 40, no. 3-4, 1992, pp. 162-6.
Pang JT, Pook MA, Eubanks JH, et al. Molecular genetic mapping of the multiple endocrine neoplasia type 1 locus. Henry Ford Hosp Med J. 1992;40(3-4):162-6.
Pang, J. T., Pook, M. A., Eubanks, J. H., Jones, C., van Heyningen, V., Evans, G. A., & Thakker, R. V. (1992). Molecular genetic mapping of the multiple endocrine neoplasia type 1 locus. Henry Ford Hospital Medical Journal, 40(3-4), 162-6.
Pang JT, et al. Molecular Genetic Mapping of the Multiple Endocrine Neoplasia Type 1 Locus. Henry Ford Hosp Med J. 1992;40(3-4):162-6. PubMed PMID: 1362397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular genetic mapping of the multiple endocrine neoplasia type 1 locus. AU - Pang,J T, AU - Pook,M A, AU - Eubanks,J H, AU - Jones,C, AU - van Heyningen,V, AU - Evans,G A, AU - Thakker,R V, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 162 EP - 6 JF - Henry Ford Hospital medical journal JO - Henry Ford Hosp Med J VL - 40 IS - 3-4 N2 - Familial multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant disorder characterized by the combined occurrence of tumors of the parathyroid glands, the endocrine pancreas, and the pituitary gland. MEN 1 tumors have previously been shown to be associated with the loss of alleles on chromosome 11, and deletion mapping studies together with family linkage studies have localized the MEN 1 gene to 11q13. A detailed genetic map around the MEN 1 locus is required to facilitate further characterization and cloning of the gene (MEN1). We have characterized a panel of seven rodent-human somatic cell hybrids which contain fragments of human chromosome 11 with breakpoints in the pericentromeric region by using eight DNA sequences (D11S149, PGA, PYGM, D11S97, INT2, D11S37, D11S533, and D11S147) to define the region containing MEN1. This will facilitate the rapid localization of additional DNA sequences in this region. In addition, we have used a highly polymorphic repetitive degenerate hexanucleotide sequence, designated D11S533, for segregation studies in one family with MEN 1. These molecular genetic approaches will help to define a precise 1 to 2 centiMorgan map around MEN1. SN - 0018-0416 UR - https://www.unboundmedicine.com/medline/citation/1362397/Molecular_genetic_mapping_of_the_multiple_endocrine_neoplasia_type_1_locus_ L2 - https://scholarlycommons.henryford.com/hfhmedjournal/vol40/iss3/4 DB - PRIME DP - Unbound Medicine ER -