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Cryptosporidiosis in HIV-seropositive patients.
Q J Med. 1992 Nov-Dec; 85(307-308):813-23.QJ

Abstract

The incidence of cryptosporidiosis in our unit has increased over the last 6 years, being diagnosed in approximately 5 per cent of all patients with HIV infection and in 21 per cent of those with AIDS, but a marked seasonal variation occurs. We have studied the course of the infection in 128 patients and identified four clinical patterns of disease: transient (28.7 per cent), chronic (59.7 per cent), fulminant (7.8 per cent) and asymptomatic (3.9 per cent). Transient disease occurred in patients with a wide range of CD4 lymphocyte counts, but was more common in less immunosuppressed patients. Fulminant disease, defined by the passage of more than 2 l of stool/day from the time of presentation, only occurred in patients with a CD4 count less than 50/mm3. This group had lost more than 7 kg in weight at presentation and more commonly had other intercurrent gastrointestinal infections. They survived for a median of only 5 weeks, compared with 20 weeks for those with chronic diarrhoea and 36 weeks for those with transient infection. The survival was unaffected by any treatment other than zidovudine. Cryptosporidiosis in HIV-infected individuals is a heterogeneous disease.

Authors+Show Affiliations

HIV/GUM Unit, Westminster Hospital, London.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1362461

Citation

Blanshard, C, et al. "Cryptosporidiosis in HIV-seropositive Patients." The Quarterly Journal of Medicine, vol. 85, no. 307-308, 1992, pp. 813-23.
Blanshard C, Jackson AM, Shanson DC, et al. Cryptosporidiosis in HIV-seropositive patients. Q J Med. 1992;85(307-308):813-23.
Blanshard, C., Jackson, A. M., Shanson, D. C., Francis, N., & Gazzard, B. G. (1992). Cryptosporidiosis in HIV-seropositive patients. The Quarterly Journal of Medicine, 85(307-308), 813-23.
Blanshard C, et al. Cryptosporidiosis in HIV-seropositive Patients. Q J Med. 1992 Nov-Dec;85(307-308):813-23. PubMed PMID: 1362461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cryptosporidiosis in HIV-seropositive patients. AU - Blanshard,C, AU - Jackson,A M, AU - Shanson,D C, AU - Francis,N, AU - Gazzard,B G, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 813 EP - 23 JF - The Quarterly journal of medicine JO - Q. J. Med. VL - 85 IS - 307-308 N2 - The incidence of cryptosporidiosis in our unit has increased over the last 6 years, being diagnosed in approximately 5 per cent of all patients with HIV infection and in 21 per cent of those with AIDS, but a marked seasonal variation occurs. We have studied the course of the infection in 128 patients and identified four clinical patterns of disease: transient (28.7 per cent), chronic (59.7 per cent), fulminant (7.8 per cent) and asymptomatic (3.9 per cent). Transient disease occurred in patients with a wide range of CD4 lymphocyte counts, but was more common in less immunosuppressed patients. Fulminant disease, defined by the passage of more than 2 l of stool/day from the time of presentation, only occurred in patients with a CD4 count less than 50/mm3. This group had lost more than 7 kg in weight at presentation and more commonly had other intercurrent gastrointestinal infections. They survived for a median of only 5 weeks, compared with 20 weeks for those with chronic diarrhoea and 36 weeks for those with transient infection. The survival was unaffected by any treatment other than zidovudine. Cryptosporidiosis in HIV-infected individuals is a heterogeneous disease. SN - 0033-5622 UR - https://www.unboundmedicine.com/medline/citation/1362461/Cryptosporidiosis_in_HIV_seropositive_patients_ L2 - http://www.diseaseinfosearch.org/result/2029 DB - PRIME DP - Unbound Medicine ER -