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The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test.
Pol J Pharmacol Pharm. 1992 Jul-Aug; 44(4):337-46.PJ

Abstract

The present study examined the effects of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test in rats and mice. Administered in a single dose or three times both examined compounds reduced the immobility time in rats. Active doses used in that test either did not change the locomotor activity or decreased it. A similar effect in both tests was shown by active (R)-enantiomers CGP 40116 and CGP 43487. Reduction of the immobility time induced by CGP 37849 and CGP 39551 in the forced swimming test in rats was antagonized by haloperidol and (+/-)-sulpiride, but not by SCH 23390 or prazosin. CGP 37849, but not CGP 39551, also reduced the immobility time in the forced swimming test in mice. The results obtained indicate that CGP 37849 and CGP 39551 induce an antidepressant-like effect in the forced swimming test, probably via an indirect dopamine activation resulting from blockade of NMDA receptors.

Authors+Show Affiliations

Institute of Pharmacology, Polish Academy of Sciences, Kraków.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1363131

Citation

Maj, J, et al. "The Effect of CGP 37849 and CGP 39551, Competitive NMDA Receptor Antagonists, in the Forced Swimming Test." Polish Journal of Pharmacology and Pharmacy, vol. 44, no. 4, 1992, pp. 337-46.
Maj J, Rogóz Z, Skuza G, et al. The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test. Pol J Pharmacol Pharm. 1992;44(4):337-46.
Maj, J., Rogóz, Z., Skuza, G., & Sowińska, H. (1992). The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test. Polish Journal of Pharmacology and Pharmacy, 44(4), 337-46.
Maj J, et al. The Effect of CGP 37849 and CGP 39551, Competitive NMDA Receptor Antagonists, in the Forced Swimming Test. Pol J Pharmacol Pharm. 1992 Jul-Aug;44(4):337-46. PubMed PMID: 1363131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test. AU - Maj,J, AU - Rogóz,Z, AU - Skuza,G, AU - Sowińska,H, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 337 EP - 46 JF - Polish journal of pharmacology and pharmacy JO - Pol J Pharmacol Pharm VL - 44 IS - 4 N2 - The present study examined the effects of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test in rats and mice. Administered in a single dose or three times both examined compounds reduced the immobility time in rats. Active doses used in that test either did not change the locomotor activity or decreased it. A similar effect in both tests was shown by active (R)-enantiomers CGP 40116 and CGP 43487. Reduction of the immobility time induced by CGP 37849 and CGP 39551 in the forced swimming test in rats was antagonized by haloperidol and (+/-)-sulpiride, but not by SCH 23390 or prazosin. CGP 37849, but not CGP 39551, also reduced the immobility time in the forced swimming test in mice. The results obtained indicate that CGP 37849 and CGP 39551 induce an antidepressant-like effect in the forced swimming test, probably via an indirect dopamine activation resulting from blockade of NMDA receptors. SN - 0301-0244 UR - https://www.unboundmedicine.com/medline/citation/1363131/The_effect_of_CGP_37849_and_CGP_39551_competitive_NMDA_receptor_antagonists_in_the_forced_swimming_test_ DB - PRIME DP - Unbound Medicine ER -