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[H2 antagonists as inhibitors of cytochrome P-450 in rat liver: in vitro and in vivo effects].
Rev Med Chil. 1992 May; 120(5):539-44.RM

Abstract

Cytochrome P-50 is a well known participant in the metabolism of xenobiotics as well as an activator or inactivator of hepatotoxic substances and carcinogenic agents. H2 antagonists, cimetidine, famotidine and ranitidine were used to inhibit cytochrome P-450 in rat liver. After 200 mg cimetidine, 85% inhibition of cytochrome P-450 in vitro and 50% in vivo were demonstrated through demethylation of aminopyrine. Inhibition was further confirmed by differential absorption spectra (Type II). The percentage inhibition obtained with famotidine or ranitidine were lower than those obtained with cimetidine. Inhibition of the microsomal oxidative system by cimetidine could lead to decreased production of superoxide radicals and protection against damage induced by toxic agents activated in the liver.

Authors+Show Affiliations

Carrasco M
Servicio de Medicina Interna, Hospital Regional de Copiapó.
Gaule C
No affiliation info available
Vega P
No affiliation info available
del Villar E
No affiliation info available

MeSH

Administration, OralAminopyrineAnimalsBiotransformationCimetidineCytochrome P-450 Enzyme InhibitorsEnzyme InductionFamotidineHemeproteinsHistamine H2 AntagonistsMaleMethylationMicrosomes, LiverMixed Function OxygenasesOxidation-ReductionRanitidineRatsRats, WistarSuperoxides

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

spa

PubMed ID

1364175

Citation

Carrasco, M, et al. "[H2 Antagonists as Inhibitors of Cytochrome P-450 in Rat Liver: in Vitro and in Vivo Effects]." Revista Medica De Chile, vol. 120, no. 5, 1992, pp. 539-44.
Carrasco M, Gaule C, Vega P, et al. [H2 antagonists as inhibitors of cytochrome P-450 in rat liver: in vitro and in vivo effects]. Rev Med Chil. 1992;120(5):539-44.
Carrasco, M., Gaule, C., Vega, P., & del Villar, E. (1992). [H2 antagonists as inhibitors of cytochrome P-450 in rat liver: in vitro and in vivo effects]. Revista Medica De Chile, 120(5), 539-44.
Carrasco M, et al. [H2 Antagonists as Inhibitors of Cytochrome P-450 in Rat Liver: in Vitro and in Vivo Effects]. Rev Med Chil. 1992;120(5):539-44. PubMed PMID: 1364175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [H2 antagonists as inhibitors of cytochrome P-450 in rat liver: in vitro and in vivo effects]. AU - Carrasco,M, AU - Gaule,C, AU - Vega,P, AU - del Villar,E, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 539 EP - 44 JF - Revista medica de Chile JO - Rev Med Chil VL - 120 IS - 5 N2 - Cytochrome P-50 is a well known participant in the metabolism of xenobiotics as well as an activator or inactivator of hepatotoxic substances and carcinogenic agents. H2 antagonists, cimetidine, famotidine and ranitidine were used to inhibit cytochrome P-450 in rat liver. After 200 mg cimetidine, 85% inhibition of cytochrome P-450 in vitro and 50% in vivo were demonstrated through demethylation of aminopyrine. Inhibition was further confirmed by differential absorption spectra (Type II). The percentage inhibition obtained with famotidine or ranitidine were lower than those obtained with cimetidine. Inhibition of the microsomal oxidative system by cimetidine could lead to decreased production of superoxide radicals and protection against damage induced by toxic agents activated in the liver. SN - 0034-9887 UR - https://www.unboundmedicine.com/medline/citation/1364175/[H2_antagonists_as_inhibitors_of_cytochrome_P_450_in_rat_liver:_in_vitro_and_in_vivo_effects]_ DB - PRIME DP - Unbound Medicine ER -