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Biogenic amines and affective disorders. A critical analysis.
Int Pharmacopsychiatry. 1976; 11(3):135-49.IP

Abstract

The evidence linking biogenic amines and affective disorders is critically reviewed. Surveyed are studies on the level of biogenic amines and their metabolites in the brain, blood, urine and cerebrospinal fluid of patients with affective conditions; the effects of biogenic amine precursors, depletors and blockers on affective states and the action of present methods of treatment of these disorders on the level of biogenic amines. Reference is also made to the existence of various disease states where abnormalities of biogenic amines exist in the absence of affective disorders. The review fails to uncover convincing evidence that affective disorders are related to abnormal levels of biogenic amines. Reasons are outlined why the "catecholamine hypothesis" and related theories can neither be proven nor disproven with the available techniques.

Authors

No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Review

Language

eng

PubMed ID

136425

Citation

Luchins, D. "Biogenic Amines and Affective Disorders. a Critical Analysis." International Pharmacopsychiatry, vol. 11, no. 3, 1976, pp. 135-49.
Luchins D. Biogenic amines and affective disorders. A critical analysis. Int Pharmacopsychiatry. 1976;11(3):135-49.
Luchins, D. (1976). Biogenic amines and affective disorders. A critical analysis. International Pharmacopsychiatry, 11(3), 135-49.
Luchins D. Biogenic Amines and Affective Disorders. a Critical Analysis. Int Pharmacopsychiatry. 1976;11(3):135-49. PubMed PMID: 136425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biogenic amines and affective disorders. A critical analysis. A1 - Luchins,D, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 135 EP - 49 JF - International pharmacopsychiatry JO - Int Pharmacopsychiatry VL - 11 IS - 3 N2 - The evidence linking biogenic amines and affective disorders is critically reviewed. Surveyed are studies on the level of biogenic amines and their metabolites in the brain, blood, urine and cerebrospinal fluid of patients with affective conditions; the effects of biogenic amine precursors, depletors and blockers on affective states and the action of present methods of treatment of these disorders on the level of biogenic amines. Reference is also made to the existence of various disease states where abnormalities of biogenic amines exist in the absence of affective disorders. The review fails to uncover convincing evidence that affective disorders are related to abnormal levels of biogenic amines. Reasons are outlined why the "catecholamine hypothesis" and related theories can neither be proven nor disproven with the available techniques. SN - 0020-8272 UR - https://www.unboundmedicine.com/medline/citation/136425/Biogenic_amines_and_affective_disorders__A_critical_analysis_ DB - PRIME DP - Unbound Medicine ER -