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Hydroxyl radical and hypochlorous acid scavenging activity of small centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis).
Phytomedicine. 2003; 10(6-7):517-22.P

Abstract

Small centaury (Centaurium erythraea Rafin.) is a herbal species with a long use in traditional medicine due to its digestive, stomachic, tonic, depurative, sedative and antipyretic properties. This species is reported to contain considerable amounts of polyphenolic compounds, namely xanthones and phenolic acids as the main constituents. Although the antiradicalar activity of some pure polyphenolic compounds is already known, it remains unclear how a complex mixture obtained from plant extracts functions against reactive oxygen species. Thus, the ability of small centaury infusion to act as a scavenger of the reactive oxygen species hydroxyl radical and hypochlorous acid was studied and compared with that of green tea (Camellia sinensis L.). Hydroxyl radical was generated in the presence of Fe3+-EDTA, ascorbate and H2O2 (Fenton system) and monitored by evaluating hydroxyl radical-induced deoxyribose degradation. The reactivity towards hypochlorous acid was determined by measuring the inhibition of hypochlorous acid-induced 5-thio-2-nitrobenzoic acid oxidation to 5,5'-dithiobis(2-nitrobenzoic acid). The obtained results demonstrate that small centaury infusion exhibits interesting antioxidant properties, expressed both by its capacity to effectively scavenge hydroxyl radical and hypochlorous acid, although with a lower activity against the second than that observed for green tea. Green tea exhibited a dual effect at the hydroxyl radical scavenging assay, stimulating deoxyribose degradation at lower dosages.

Authors+Show Affiliations

CEQUP/Serviço de Farmacognosia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

13678237

Citation

Valentão, P, et al. "Hydroxyl Radical and Hypochlorous Acid Scavenging Activity of Small Centaury (Centaurium Erythraea) Infusion. a Comparative Study With Green Tea (Camellia Sinensis)." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 10, no. 6-7, 2003, pp. 517-22.
Valentão P, Fernandes E, Carvalho F, et al. Hydroxyl radical and hypochlorous acid scavenging activity of small centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis). Phytomedicine. 2003;10(6-7):517-22.
Valentão, P., Fernandes, E., Carvalho, F., Andrade, P. B., Seabra, R. M., & Bastos, M. L. (2003). Hydroxyl radical and hypochlorous acid scavenging activity of small centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis). Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 10(6-7), 517-22.
Valentão P, et al. Hydroxyl Radical and Hypochlorous Acid Scavenging Activity of Small Centaury (Centaurium Erythraea) Infusion. a Comparative Study With Green Tea (Camellia Sinensis). Phytomedicine. 2003;10(6-7):517-22. PubMed PMID: 13678237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydroxyl radical and hypochlorous acid scavenging activity of small centaury (Centaurium erythraea) infusion. A comparative study with green tea (Camellia sinensis). AU - Valentão,P, AU - Fernandes,E, AU - Carvalho,F, AU - Andrade,P B, AU - Seabra,R M, AU - Bastos,M L, PY - 2003/9/19/pubmed PY - 2004/1/6/medline PY - 2003/9/19/entrez SP - 517 EP - 22 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 10 IS - 6-7 N2 - Small centaury (Centaurium erythraea Rafin.) is a herbal species with a long use in traditional medicine due to its digestive, stomachic, tonic, depurative, sedative and antipyretic properties. This species is reported to contain considerable amounts of polyphenolic compounds, namely xanthones and phenolic acids as the main constituents. Although the antiradicalar activity of some pure polyphenolic compounds is already known, it remains unclear how a complex mixture obtained from plant extracts functions against reactive oxygen species. Thus, the ability of small centaury infusion to act as a scavenger of the reactive oxygen species hydroxyl radical and hypochlorous acid was studied and compared with that of green tea (Camellia sinensis L.). Hydroxyl radical was generated in the presence of Fe3+-EDTA, ascorbate and H2O2 (Fenton system) and monitored by evaluating hydroxyl radical-induced deoxyribose degradation. The reactivity towards hypochlorous acid was determined by measuring the inhibition of hypochlorous acid-induced 5-thio-2-nitrobenzoic acid oxidation to 5,5'-dithiobis(2-nitrobenzoic acid). The obtained results demonstrate that small centaury infusion exhibits interesting antioxidant properties, expressed both by its capacity to effectively scavenge hydroxyl radical and hypochlorous acid, although with a lower activity against the second than that observed for green tea. Green tea exhibited a dual effect at the hydroxyl radical scavenging assay, stimulating deoxyribose degradation at lower dosages. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/13678237/Hydroxyl_radical_and_hypochlorous_acid_scavenging_activity_of_small_centaury__Centaurium_erythraea__infusion__A_comparative_study_with_green_tea__Camellia_sinensis__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(04)70257-3 DB - PRIME DP - Unbound Medicine ER -