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Evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study.

Abstract

The plant extracts of some commonly used spices were examined for their possible regulatory effect on nitric oxide (NO) levels using sodium nitroprusside as a NO donor in vitro. Most of the extracts tested demonstrated direct scavenging of NO and exhibited significant activity and the potency of scavenging activity was in the following order: Foeniculum vulgare (aqueous) > Citrus limettiodes > Murraya koenigii (seed, aqueous) > Murraya koenigii (leaf, aqueous) > Curcuma aromatica (aqueous) > Murraya koenigii (leaf, dichloromethane:methanol) > Mentha arvensis (chloroform) > Mentha arvensis (aqueous) > Curcuma longa > Gingko biloba > Foeniculum vulgare (dichloromethane:methanol) > Zingiber officinale (aqueous) > Curcuma aromatica (ethanolic) > Murraya koenigii (seed, dichloromethane:methanol). All the evaluated extracts exhibited a dose-dependent NO scavenging activity. The aqueous extract of Foeniculum vulgare showed a greatest NO scavenging effect of 79.75% at 62.5 microg/mL as compared to the positive control, Gingko biloba where 36.22% scavenging was observed at similar concentration. The present results suggest that these spices might be potent and novel therapeutic agents for scavenging of NO and the regulation of pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite.

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  • Authors+Show Affiliations

    ,

    Department of Radiobiology Kasturba Medical College, Manipal-576 119, Karnataka, India.

    , ,

    Source

    Die Nahrung 47:4 2003 Aug pg 261-4

    MeSH

    Free Radical Scavengers
    Nitric Oxide
    Nitroprusside
    Plant Extracts
    Spices

    Pub Type(s)

    Evaluation Studies
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    13678266

    Citation

    Baliga, Manjeshwar Shrinath, et al. "Evaluation of Nitric Oxide Scavenging Activity of Certain Spices in Vitro: a Preliminary Study." Die Nahrung, vol. 47, no. 4, 2003, pp. 261-4.
    Baliga MS, Jagetia GC, Rao SK, et al. Evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study. Nahrung. 2003;47(4):261-4.
    Baliga, M. S., Jagetia, G. C., Rao, S. K., & Babu, K. (2003). Evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study. Die Nahrung, 47(4), pp. 261-4.
    Baliga MS, et al. Evaluation of Nitric Oxide Scavenging Activity of Certain Spices in Vitro: a Preliminary Study. Nahrung. 2003;47(4):261-4. PubMed PMID: 13678266.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study. AU - Baliga,Manjeshwar Shrinath, AU - Jagetia,Ganesh Chandra, AU - Rao,Shaival Kamalaksha, AU - Babu,Kiran, PY - 2003/9/19/pubmed PY - 2003/12/24/medline PY - 2003/9/19/entrez SP - 261 EP - 4 JF - Die Nahrung JO - Nahrung VL - 47 IS - 4 N2 - The plant extracts of some commonly used spices were examined for their possible regulatory effect on nitric oxide (NO) levels using sodium nitroprusside as a NO donor in vitro. Most of the extracts tested demonstrated direct scavenging of NO and exhibited significant activity and the potency of scavenging activity was in the following order: Foeniculum vulgare (aqueous) > Citrus limettiodes > Murraya koenigii (seed, aqueous) > Murraya koenigii (leaf, aqueous) > Curcuma aromatica (aqueous) > Murraya koenigii (leaf, dichloromethane:methanol) > Mentha arvensis (chloroform) > Mentha arvensis (aqueous) > Curcuma longa > Gingko biloba > Foeniculum vulgare (dichloromethane:methanol) > Zingiber officinale (aqueous) > Curcuma aromatica (ethanolic) > Murraya koenigii (seed, dichloromethane:methanol). All the evaluated extracts exhibited a dose-dependent NO scavenging activity. The aqueous extract of Foeniculum vulgare showed a greatest NO scavenging effect of 79.75% at 62.5 microg/mL as compared to the positive control, Gingko biloba where 36.22% scavenging was observed at similar concentration. The present results suggest that these spices might be potent and novel therapeutic agents for scavenging of NO and the regulation of pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite. SN - 0027-769X UR - https://www.unboundmedicine.com/medline/citation/13678266/Evaluation_of_nitric_oxide_scavenging_activity_of_certain_spices_in_vitro:_a_preliminary_study_ L2 - https://doi.org/10.1002/food.200390061 DB - PRIME DP - Unbound Medicine ER -