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The Rad52-Rad59 complex interacts with Rad51 and replication protein A.
DNA Repair (Amst). 2003 Oct 07; 2(10):1127-34.DR

Abstract

The RAD52 gene is essential for homology-dependent repair of double-strand breaks in Saccharomyces cerevisiae. Rad52 forms complexes with Rad51, replication protein A (RPA) or Rad59 and its presence is essential for the formation of Rad51-Rad52-Rad59 and RPA-Rad52-Rad59 complexes. The N-terminal region of Rad52, which is required for self-interaction to form a ring structure, is required for interaction with Rad59. Rad59 also shows self-interaction suggesting the formation of heteromeric and homomeric rings of Rad52 and Rad59. In wild-type cells, we propose the Rad51-Rad52-Rad59 complex is involved in conservative recombination events, including gene conversion and reciprocal recombination, whereas the Rad52-Rad59 complex participates in single-strand annealing.

Authors+Show Affiliations

Department of Microbiology and Institute of Cancer Research, Columbia University College of Physicians and Surgeons, 701 W 168th St., New York, NY 10032, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

13679150

Citation

Davis, Allison P., and Lorraine S. Symington. "The Rad52-Rad59 Complex Interacts With Rad51 and Replication Protein A." DNA Repair, vol. 2, no. 10, 2003, pp. 1127-34.
Davis AP, Symington LS. The Rad52-Rad59 complex interacts with Rad51 and replication protein A. DNA Repair (Amst). 2003;2(10):1127-34.
Davis, A. P., & Symington, L. S. (2003). The Rad52-Rad59 complex interacts with Rad51 and replication protein A. DNA Repair, 2(10), 1127-34.
Davis AP, Symington LS. The Rad52-Rad59 Complex Interacts With Rad51 and Replication Protein A. DNA Repair (Amst). 2003 Oct 7;2(10):1127-34. PubMed PMID: 13679150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Rad52-Rad59 complex interacts with Rad51 and replication protein A. AU - Davis,Allison P, AU - Symington,Lorraine S, PY - 2003/9/19/pubmed PY - 2004/6/5/medline PY - 2003/9/19/entrez SP - 1127 EP - 34 JF - DNA repair JO - DNA Repair (Amst) VL - 2 IS - 10 N2 - The RAD52 gene is essential for homology-dependent repair of double-strand breaks in Saccharomyces cerevisiae. Rad52 forms complexes with Rad51, replication protein A (RPA) or Rad59 and its presence is essential for the formation of Rad51-Rad52-Rad59 and RPA-Rad52-Rad59 complexes. The N-terminal region of Rad52, which is required for self-interaction to form a ring structure, is required for interaction with Rad59. Rad59 also shows self-interaction suggesting the formation of heteromeric and homomeric rings of Rad52 and Rad59. In wild-type cells, we propose the Rad51-Rad52-Rad59 complex is involved in conservative recombination events, including gene conversion and reciprocal recombination, whereas the Rad52-Rad59 complex participates in single-strand annealing. SN - 1568-7864 UR - https://www.unboundmedicine.com/medline/citation/13679150/The_Rad52_Rad59_complex_interacts_with_Rad51_and_replication_protein_A_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568786403001216 DB - PRIME DP - Unbound Medicine ER -