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Antitumor activity of some polysaccharides isolated from a Chinese mushroom, "huangmo", the fruiting body of Hohenbuehelia serotina.
Agric Biol Chem. 1991 Nov; 55(11):2701-10.AB

Abstract

Polysaccharides were extracted from a Chinese mushroom, "Huangmo" with hot water (FI), 1% ammonium oxalate solution (FII), and 5% sodium hydroxide (FIII) and 20 more polysaccharides were isolated by ethanol precipitation, ion-exchange chromatography, gel filtration, and affinity chromatography. Of the six polysaccharides obtained, FI0, FA-1, FA-2, FII-2, FIII-1-b, and FIII-2-b were selected on the basis of the results of the antitumor activity test (the Sarcoma 180/mice, i.p. method). Six fractions which showed relatively high activities were examined: FI0, a mixture of galactose-containing heteroglycan and beta-D-glucan; FA-1 and -2, beta-D-glucan with galactose-containing hetero-glycan and protein; FII-2, beta-D-glucan; and FIII-1-b and FIII-2-b, (1----6)-beta-D-glucosyl branched (1----3)-beta-D-glucan.

Authors+Show Affiliations

Ma Y
Faculty of Basic Medical Science, Norman Bethune University of Medical Sciences, Changchun, Jilin, China.
Mizuno T
No affiliation info available
Ito H
No affiliation info available

MeSH

Amino AcidsAnimalsAntineoplastic AgentsBasidiomycotaChemical FractionationChitinDrugs, Chinese HerbalHydrogen-Ion ConcentrationMagnetic Resonance SpectroscopyMiceMolecular WeightOxalatesPolysaccharidesSarcoma, ExperimentalSodium HydroxideSolubility

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1368746

Citation

Ma, Y, et al. "Antitumor Activity of some Polysaccharides Isolated From a Chinese Mushroom, "huangmo", the Fruiting Body of Hohenbuehelia Serotina." Agricultural and Biological Chemistry, vol. 55, no. 11, 1991, pp. 2701-10.
Ma Y, Mizuno T, Ito H. Antitumor activity of some polysaccharides isolated from a Chinese mushroom, "huangmo", the fruiting body of Hohenbuehelia serotina. Agric Biol Chem. 1991;55(11):2701-10.
Ma, Y., Mizuno, T., & Ito, H. (1991). Antitumor activity of some polysaccharides isolated from a Chinese mushroom, "huangmo", the fruiting body of Hohenbuehelia serotina. Agricultural and Biological Chemistry, 55(11), 2701-10.
Ma Y, Mizuno T, Ito H. Antitumor Activity of some Polysaccharides Isolated From a Chinese Mushroom, "huangmo", the Fruiting Body of Hohenbuehelia Serotina. Agric Biol Chem. 1991;55(11):2701-10. PubMed PMID: 1368746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor activity of some polysaccharides isolated from a Chinese mushroom, "huangmo", the fruiting body of Hohenbuehelia serotina. AU - Ma,Y, AU - Mizuno,T, AU - Ito,H, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 2701 EP - 10 JF - Agricultural and biological chemistry JO - Agric Biol Chem VL - 55 IS - 11 N2 - Polysaccharides were extracted from a Chinese mushroom, "Huangmo" with hot water (FI), 1% ammonium oxalate solution (FII), and 5% sodium hydroxide (FIII) and 20 more polysaccharides were isolated by ethanol precipitation, ion-exchange chromatography, gel filtration, and affinity chromatography. Of the six polysaccharides obtained, FI0, FA-1, FA-2, FII-2, FIII-1-b, and FIII-2-b were selected on the basis of the results of the antitumor activity test (the Sarcoma 180/mice, i.p. method). Six fractions which showed relatively high activities were examined: FI0, a mixture of galactose-containing heteroglycan and beta-D-glucan; FA-1 and -2, beta-D-glucan with galactose-containing hetero-glycan and protein; FII-2, beta-D-glucan; and FIII-1-b and FIII-2-b, (1----6)-beta-D-glucosyl branched (1----3)-beta-D-glucan. SN - 0002-1369 UR - https://www.unboundmedicine.com/medline/citation/1368746/Antitumor_activity_of_some_polysaccharides_isolated_from_a_Chinese_mushroom_"huangmo"_the_fruiting_body_of_Hohenbuehelia_serotina_ DB - PRIME DP - Unbound Medicine ER -