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Effect of fetal haemoglobin on the accuracy of pulse oximetry in preterm infants.
J Paediatr Child Health. 1992 Feb; 28(1):43-6.JP

Abstract

Pulse oximeters are programmed with a calibration curve derived from studies done in adults. Whether fetal haemoglobin levels affect their reliability is unclear. This study reports the accuracy of pulse oximetry in 22 preterm infants (mean 31 weeks, range 25-36 weeks gestation) between 1 h and 73 days of age. Oxygen saturation obtained from a Nellcor N-200 pulse oximeter (SpO2) was compared with simultaneous arterial values (functional SaO2) measured by a Radiometer OSM3 Hemoximeter over a SpO2 range of 83-99%. Fetal haemoglobin (HbF), carboxyhaemoglobin (HbCO) and methaemoglobin (HbMet) measured by the hemoximeter ranged between 0-100%, 0-3.5% and 0-0.8% respectively. Linear regression analysis revealed a close correlation between SpO2 and functional SaO2 (SpO2 = 0.75 SaO2 + 24.43, r = 0.88, P less than 0.001) over a wide range of values for PCV, heart rate, blood pressure, PaO2, PaCO2 and pH. The mean SpO2-SaO2 difference of 1.3, (s.d. 2.5%, P less than 0.001) was unaffected by HgF, HbCO or HbMet but was increased in infants receiving inotropic support. We conclude that the Nellcor N-200 pulse oximeter gives reliable oxygen saturation measurements unaffected by the HbF level in preterm infants.

Authors+Show Affiliations

Rajadurai VS
Department of Paediatrics, Monash Medical Centre, Melbourne, Victoria, Australia.
Walker AM
No affiliation info available
Yu VY
No affiliation info available
Oates A
No affiliation info available

MeSH

Fetal HemoglobinHumansInfantInfant, NewbornInfant, Premature, DiseasesOximetryOxygenReproducibility of Results

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1372809

Citation

Rajadurai, V S., et al. "Effect of Fetal Haemoglobin On the Accuracy of Pulse Oximetry in Preterm Infants." Journal of Paediatrics and Child Health, vol. 28, no. 1, 1992, pp. 43-6.
Rajadurai VS, Walker AM, Yu VY, et al. Effect of fetal haemoglobin on the accuracy of pulse oximetry in preterm infants. J Paediatr Child Health. 1992;28(1):43-6.
Rajadurai, V. S., Walker, A. M., Yu, V. Y., & Oates, A. (1992). Effect of fetal haemoglobin on the accuracy of pulse oximetry in preterm infants. Journal of Paediatrics and Child Health, 28(1), 43-6.
Rajadurai VS, et al. Effect of Fetal Haemoglobin On the Accuracy of Pulse Oximetry in Preterm Infants. J Paediatr Child Health. 1992;28(1):43-6. PubMed PMID: 1372809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fetal haemoglobin on the accuracy of pulse oximetry in preterm infants. AU - Rajadurai,V S, AU - Walker,A M, AU - Yu,V Y, AU - Oates,A, PY - 1992/2/1/pubmed PY - 1992/2/1/medline PY - 1992/2/1/entrez SP - 43 EP - 6 JF - Journal of paediatrics and child health JO - J Paediatr Child Health VL - 28 IS - 1 N2 - Pulse oximeters are programmed with a calibration curve derived from studies done in adults. Whether fetal haemoglobin levels affect their reliability is unclear. This study reports the accuracy of pulse oximetry in 22 preterm infants (mean 31 weeks, range 25-36 weeks gestation) between 1 h and 73 days of age. Oxygen saturation obtained from a Nellcor N-200 pulse oximeter (SpO2) was compared with simultaneous arterial values (functional SaO2) measured by a Radiometer OSM3 Hemoximeter over a SpO2 range of 83-99%. Fetal haemoglobin (HbF), carboxyhaemoglobin (HbCO) and methaemoglobin (HbMet) measured by the hemoximeter ranged between 0-100%, 0-3.5% and 0-0.8% respectively. Linear regression analysis revealed a close correlation between SpO2 and functional SaO2 (SpO2 = 0.75 SaO2 + 24.43, r = 0.88, P less than 0.001) over a wide range of values for PCV, heart rate, blood pressure, PaO2, PaCO2 and pH. The mean SpO2-SaO2 difference of 1.3, (s.d. 2.5%, P less than 0.001) was unaffected by HgF, HbCO or HbMet but was increased in infants receiving inotropic support. We conclude that the Nellcor N-200 pulse oximeter gives reliable oxygen saturation measurements unaffected by the HbF level in preterm infants. SN - 1034-4810 UR - https://www.unboundmedicine.com/medline/citation/1372809/Effect_of_fetal_haemoglobin_on_the_accuracy_of_pulse_oximetry_in_preterm_infants_ DB - PRIME DP - Unbound Medicine ER -