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Effect of endothelium on the actions of sympathetic and sensory nerves in the perfused rat mesentery.
Eur J Pharmacol. 1992 Jan 07; 210(1):23-30.EJ

Abstract

We and others have previously demonstrated that pretreatment with capsaicin produces an augmentation of vasoconstrictor responses to transmural nerve stimulation. In the present study, removal of endothelium by saponin or inhibition of nitric oxide synthesis by N omega-nitro-L-arginine methyl ester produced an augmentation of vasoconstrictor responses to transmural nerve stimulation, responses which were further potentiated after treatment with capsaicin to desensitize sensory nerves. Capsaicin treatment decreased vasodilator responses to acetylcholine, but only at low acetylcholine concentrations. Potentiation by capsaicin of vasoconstrictor responses to transmural nerve stimulation was not affected by indomethacin. In the presence of guanethidine and methoxamine, transmural nerve stimulation caused vasodilator responses in the perfused rat mesentery. These responses were unaffected by removal of endothelium, as were vasodilator responses to exogenous calcitonin gene-related peptide (CGRP). In contrast, substance P did not produce any relaxation in the methoxamine-contracted mesentery. This study suggests that facilitation of vasoconstrictor responses to transmural nerve stimulation after capsaicin treatment primarily reflects inhibition of sensory nerve effects resulting in an increase of sympathetic vasoconstrictor actions. The present results also suggest that vasodilator responses to sensory nerve activation or exogenous CGRP are endothelium-independent and that substance P does not significantly contribute to modulation of vascular tone in the rat mesentery.

Authors+Show Affiliations

Department of Pharmacology, College of Medicine, University of California, Irvine 92717.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1376271

Citation

Li, Y J., and S P. Duckles. "Effect of Endothelium On the Actions of Sympathetic and Sensory Nerves in the Perfused Rat Mesentery." European Journal of Pharmacology, vol. 210, no. 1, 1992, pp. 23-30.
Li YJ, Duckles SP. Effect of endothelium on the actions of sympathetic and sensory nerves in the perfused rat mesentery. Eur J Pharmacol. 1992;210(1):23-30.
Li, Y. J., & Duckles, S. P. (1992). Effect of endothelium on the actions of sympathetic and sensory nerves in the perfused rat mesentery. European Journal of Pharmacology, 210(1), 23-30.
Li YJ, Duckles SP. Effect of Endothelium On the Actions of Sympathetic and Sensory Nerves in the Perfused Rat Mesentery. Eur J Pharmacol. 1992 Jan 7;210(1):23-30. PubMed PMID: 1376271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of endothelium on the actions of sympathetic and sensory nerves in the perfused rat mesentery. AU - Li,Y J, AU - Duckles,S P, PY - 1992/1/7/pubmed PY - 1992/1/7/medline PY - 1992/1/7/entrez SP - 23 EP - 30 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 210 IS - 1 N2 - We and others have previously demonstrated that pretreatment with capsaicin produces an augmentation of vasoconstrictor responses to transmural nerve stimulation. In the present study, removal of endothelium by saponin or inhibition of nitric oxide synthesis by N omega-nitro-L-arginine methyl ester produced an augmentation of vasoconstrictor responses to transmural nerve stimulation, responses which were further potentiated after treatment with capsaicin to desensitize sensory nerves. Capsaicin treatment decreased vasodilator responses to acetylcholine, but only at low acetylcholine concentrations. Potentiation by capsaicin of vasoconstrictor responses to transmural nerve stimulation was not affected by indomethacin. In the presence of guanethidine and methoxamine, transmural nerve stimulation caused vasodilator responses in the perfused rat mesentery. These responses were unaffected by removal of endothelium, as were vasodilator responses to exogenous calcitonin gene-related peptide (CGRP). In contrast, substance P did not produce any relaxation in the methoxamine-contracted mesentery. This study suggests that facilitation of vasoconstrictor responses to transmural nerve stimulation after capsaicin treatment primarily reflects inhibition of sensory nerve effects resulting in an increase of sympathetic vasoconstrictor actions. The present results also suggest that vasodilator responses to sensory nerve activation or exogenous CGRP are endothelium-independent and that substance P does not significantly contribute to modulation of vascular tone in the rat mesentery. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/1376271/Effect_of_endothelium_on_the_actions_of_sympathetic_and_sensory_nerves_in_the_perfused_rat_mesentery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(92)90647-M DB - PRIME DP - Unbound Medicine ER -