Tags

Type your tag names separated by a space and hit enter

Recovery from lateralized neocortical damage: dissociation between amphetamine-induced asymmetry in behavior and striatal dopamine neurotransmission in vivo.
Brain Res 1992; 571(2):248-59BR

Abstract

It has been hypothesized that neocortical damage is accompanied by secondary changes in other brain areas (the shock or diaschisis of von Monakow), which contributes to initial non-specific behavioral depression. The relation between behavioral changes and dopamine (DA), serotonin (5-HT), and their metabolites, measured with intracerebral microdialysis in freely moving rats and by tissue assay postmortem, was examined during postsurgical recovery from unilateral hemidecortications. Rats were tested for rotational asymmetry and extracellular concentration of DA was measured both during rest and after amphetamine (1.5 mg/kg). It was found that: (1) during the first few postsurgical days the hemidecorticate rats rotated ipsilateral to their lesions after amphetamine but thereafter on tests given up to 121 days postsurgery concentration of DA or its metabolites at any time after surgery; (3) the 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA) was elevated acutely for a few days following surgery; (4) during the first 3 postoperative days, both baseline extracellular 3,4-dihydroxyphenylacetic acid (DOPAC) and amphetamine-induced DA release were significantly elevated bilaterally. These findings demonstrate that the acute behavioral asymmetry in rotation produced by hemidecortication is not related to unilateral changes in striatal DA activity and its metabolites. Thus, the behavioral asymmetries might be related to other striatal changes (i.e. 5-HIAA) or other damage, such as to the corticospinal projections of the lesioned hemisphere. Nevertheless, unilateral lesions did produce acute bilateral increases in DA levels, which may be a correlate of generalized neural shock produced by the lesion.

Authors+Show Affiliations

Department of Psychology, University of Lethbridge, Alta, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1377087

Citation

Castañeda, E, et al. "Recovery From Lateralized Neocortical Damage: Dissociation Between Amphetamine-induced Asymmetry in Behavior and Striatal Dopamine Neurotransmission in Vivo." Brain Research, vol. 571, no. 2, 1992, pp. 248-59.
Castañeda E, Whishaw IQ, Robinson TE. Recovery from lateralized neocortical damage: dissociation between amphetamine-induced asymmetry in behavior and striatal dopamine neurotransmission in vivo. Brain Res. 1992;571(2):248-59.
Castañeda, E., Whishaw, I. Q., & Robinson, T. E. (1992). Recovery from lateralized neocortical damage: dissociation between amphetamine-induced asymmetry in behavior and striatal dopamine neurotransmission in vivo. Brain Research, 571(2), pp. 248-59.
Castañeda E, Whishaw IQ, Robinson TE. Recovery From Lateralized Neocortical Damage: Dissociation Between Amphetamine-induced Asymmetry in Behavior and Striatal Dopamine Neurotransmission in Vivo. Brain Res. 1992 Feb 7;571(2):248-59. PubMed PMID: 1377087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recovery from lateralized neocortical damage: dissociation between amphetamine-induced asymmetry in behavior and striatal dopamine neurotransmission in vivo. AU - Castañeda,E, AU - Whishaw,I Q, AU - Robinson,T E, PY - 1992/2/7/pubmed PY - 1992/2/7/medline PY - 1992/2/7/entrez SP - 248 EP - 59 JF - Brain research JO - Brain Res. VL - 571 IS - 2 N2 - It has been hypothesized that neocortical damage is accompanied by secondary changes in other brain areas (the shock or diaschisis of von Monakow), which contributes to initial non-specific behavioral depression. The relation between behavioral changes and dopamine (DA), serotonin (5-HT), and their metabolites, measured with intracerebral microdialysis in freely moving rats and by tissue assay postmortem, was examined during postsurgical recovery from unilateral hemidecortications. Rats were tested for rotational asymmetry and extracellular concentration of DA was measured both during rest and after amphetamine (1.5 mg/kg). It was found that: (1) during the first few postsurgical days the hemidecorticate rats rotated ipsilateral to their lesions after amphetamine but thereafter on tests given up to 121 days postsurgery concentration of DA or its metabolites at any time after surgery; (3) the 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA) was elevated acutely for a few days following surgery; (4) during the first 3 postoperative days, both baseline extracellular 3,4-dihydroxyphenylacetic acid (DOPAC) and amphetamine-induced DA release were significantly elevated bilaterally. These findings demonstrate that the acute behavioral asymmetry in rotation produced by hemidecortication is not related to unilateral changes in striatal DA activity and its metabolites. Thus, the behavioral asymmetries might be related to other striatal changes (i.e. 5-HIAA) or other damage, such as to the corticospinal projections of the lesioned hemisphere. Nevertheless, unilateral lesions did produce acute bilateral increases in DA levels, which may be a correlate of generalized neural shock produced by the lesion. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/1377087/Recovery_from_lateralized_neocortical_damage:_dissociation_between_amphetamine_induced_asymmetry_in_behavior_and_striatal_dopamine_neurotransmission_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-8993(92)90662-S DB - PRIME DP - Unbound Medicine ER -