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In vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment.
Brain Res 1992; 571(2):330-7BR

Abstract

In vivo microdialysis procedures were used to assess the effects of repeated amphetamine administration on behavior and regional brain DA dynamics in freely moving rats. Pretreatment with amphetamine (2.5 or 3.0 mg/kg) for 4-6 days did not alter baseline DA or its metabolites in caudate or accumbens 48 h or 6 days after the last injection. However, whereas this dosage regimen revealed a profound behavioral sensitization in response to challenge with amphetamine (2.5 mg/kg), including a more rapid onset and intensification of stereotypy, the DA response was significantly diminished in both brain regions. In addition, the ratio of caudate to accumbens DA, either before or after amphetamine challenge, was not altered by the pretreatment regimen. These results are consistent with our previous suggestion that there is a dissociation between the DA and behavioral responses to amphetamine, and therefore that other neurotransmitter systems and/or mechanisms significantly contribute to the amphetamine response profile. Furthermore, DA effects may represent only one, albeit critical, aspect in a time-dependent sequence of changes underlying stimulant sensitization.

Authors+Show Affiliations

Department of Psychiatry, University of California, San Diego, La Jolla 92093-0603.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1377088

Citation

Segal, D S., and R Kuczenski. "In Vivo Microdialysis Reveals a Diminished Amphetamine-induced DA Response Corresponding to Behavioral Sensitization Produced By Repeated Amphetamine Pretreatment." Brain Research, vol. 571, no. 2, 1992, pp. 330-7.
Segal DS, Kuczenski R. In vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment. Brain Res. 1992;571(2):330-7.
Segal, D. S., & Kuczenski, R. (1992). In vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment. Brain Research, 571(2), pp. 330-7.
Segal DS, Kuczenski R. In Vivo Microdialysis Reveals a Diminished Amphetamine-induced DA Response Corresponding to Behavioral Sensitization Produced By Repeated Amphetamine Pretreatment. Brain Res. 1992 Feb 7;571(2):330-7. PubMed PMID: 1377088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment. AU - Segal,D S, AU - Kuczenski,R, PY - 1992/2/7/pubmed PY - 1992/2/7/medline PY - 1992/2/7/entrez SP - 330 EP - 7 JF - Brain research JO - Brain Res. VL - 571 IS - 2 N2 - In vivo microdialysis procedures were used to assess the effects of repeated amphetamine administration on behavior and regional brain DA dynamics in freely moving rats. Pretreatment with amphetamine (2.5 or 3.0 mg/kg) for 4-6 days did not alter baseline DA or its metabolites in caudate or accumbens 48 h or 6 days after the last injection. However, whereas this dosage regimen revealed a profound behavioral sensitization in response to challenge with amphetamine (2.5 mg/kg), including a more rapid onset and intensification of stereotypy, the DA response was significantly diminished in both brain regions. In addition, the ratio of caudate to accumbens DA, either before or after amphetamine challenge, was not altered by the pretreatment regimen. These results are consistent with our previous suggestion that there is a dissociation between the DA and behavioral responses to amphetamine, and therefore that other neurotransmitter systems and/or mechanisms significantly contribute to the amphetamine response profile. Furthermore, DA effects may represent only one, albeit critical, aspect in a time-dependent sequence of changes underlying stimulant sensitization. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/1377088/In_vivo_microdialysis_reveals_a_diminished_amphetamine_induced_DA_response_corresponding_to_behavioral_sensitization_produced_by_repeated_amphetamine_pretreatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-8993(92)90672-V DB - PRIME DP - Unbound Medicine ER -