Tags

Type your tag names separated by a space and hit enter

[A case of acute idiopathic pandysautonomia--a histochemical study of sural nerve by acetylcholinesterase staining].
Rinsho Shinkeigaku. 1992 Feb; 32(2):199-202.RS

Abstract

A 30-year-old man had an acute onset of orthostatic lightheadedness, sweating disturbance, paroxysmal cough and loss of potency. These symptoms reached the peak in two weeks, and then remitted very slowly. He was admitted to our hospital for further evaluation when he was 39 years old. Neurological examinations revealed right Horner's syndrome, dry skin and impotence, but neither motor nor sensory system was impaired. No abnormalities were found on routine examinations of the blood and cerebrospinal fluid, motor and sensory nerve velocities, computed tomography and electroencephalography. On sural nerve biopsy, the density of unmyelinated fibers was mildly decreased (13,857/mm2), whereas that of myelinated fibers was normal (7,220/mm2). Autonomic function tests disclosed orthostatic hypotension (-31 mmHg) on tilting, reduced levels of serum noradrenaline and vanillyl mandelic acid, supersensitive responses to noradrenaline infusion and adrenaline eye-dripping, severe sweating impairment and complete absence of sympathetic skin response. On the other hand, Aschner's test, Czermak's test and coefficient variation of R-R intervals were all normal. These results suggested that the chief lesion was located in the postganglionic fiber of sympathetic efferent pathway. We (Hayashi et al, 1990) quantified acetylcholinesterase (AchE)-positive fibers in the specimens of sural nerve biopsy, and reported that the density of AchE-positive fibers was correlated to the function of sympathetic postganglionic fibers. The density of AchE-positive fibers in the present case of acute idiopathic pandysautonomia (AIPD) was severely decreased to 225/mm2 by optical microscopy (control: 5,703 +/- 1,289/mm2), and to 2,996/mm2 by electron microscopy (control: 14,112 +/- 3,987/mm2).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Neurology, Faculty of Medicine, Tokyo Medical and Dental University.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

1377106

Citation

Itoh, Y, et al. "[A Case of Acute Idiopathic Pandysautonomia--a Histochemical Study of Sural Nerve By Acetylcholinesterase Staining]." Rinsho Shinkeigaku = Clinical Neurology, vol. 32, no. 2, 1992, pp. 199-202.
Itoh Y, Yokota T, Hayashi M, et al. [A case of acute idiopathic pandysautonomia--a histochemical study of sural nerve by acetylcholinesterase staining]. Rinsho Shinkeigaku. 1992;32(2):199-202.
Itoh, Y., Yokota, T., Hayashi, M., Wada, Y., & Tsukagoshi, H. (1992). [A case of acute idiopathic pandysautonomia--a histochemical study of sural nerve by acetylcholinesterase staining]. Rinsho Shinkeigaku = Clinical Neurology, 32(2), 199-202.
Itoh Y, et al. [A Case of Acute Idiopathic Pandysautonomia--a Histochemical Study of Sural Nerve By Acetylcholinesterase Staining]. Rinsho Shinkeigaku. 1992;32(2):199-202. PubMed PMID: 1377106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A case of acute idiopathic pandysautonomia--a histochemical study of sural nerve by acetylcholinesterase staining]. AU - Itoh,Y, AU - Yokota,T, AU - Hayashi,M, AU - Wada,Y, AU - Tsukagoshi,H, PY - 1992/2/1/pubmed PY - 1992/2/1/medline PY - 1992/2/1/entrez SP - 199 EP - 202 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 32 IS - 2 N2 - A 30-year-old man had an acute onset of orthostatic lightheadedness, sweating disturbance, paroxysmal cough and loss of potency. These symptoms reached the peak in two weeks, and then remitted very slowly. He was admitted to our hospital for further evaluation when he was 39 years old. Neurological examinations revealed right Horner's syndrome, dry skin and impotence, but neither motor nor sensory system was impaired. No abnormalities were found on routine examinations of the blood and cerebrospinal fluid, motor and sensory nerve velocities, computed tomography and electroencephalography. On sural nerve biopsy, the density of unmyelinated fibers was mildly decreased (13,857/mm2), whereas that of myelinated fibers was normal (7,220/mm2). Autonomic function tests disclosed orthostatic hypotension (-31 mmHg) on tilting, reduced levels of serum noradrenaline and vanillyl mandelic acid, supersensitive responses to noradrenaline infusion and adrenaline eye-dripping, severe sweating impairment and complete absence of sympathetic skin response. On the other hand, Aschner's test, Czermak's test and coefficient variation of R-R intervals were all normal. These results suggested that the chief lesion was located in the postganglionic fiber of sympathetic efferent pathway. We (Hayashi et al, 1990) quantified acetylcholinesterase (AchE)-positive fibers in the specimens of sural nerve biopsy, and reported that the density of AchE-positive fibers was correlated to the function of sympathetic postganglionic fibers. The density of AchE-positive fibers in the present case of acute idiopathic pandysautonomia (AIPD) was severely decreased to 225/mm2 by optical microscopy (control: 5,703 +/- 1,289/mm2), and to 2,996/mm2 by electron microscopy (control: 14,112 +/- 3,987/mm2).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0009-918X UR - https://www.unboundmedicine.com/medline/citation/1377106/[A_case_of_acute_idiopathic_pandysautonomia__a_histochemical_study_of_sural_nerve_by_acetylcholinesterase_staining]_ L2 - https://medlineplus.gov/autonomicnervoussystemdisorders.html DB - PRIME DP - Unbound Medicine ER -