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Urinary concentrations of beta core fragment of hCG throughout pregnancy.
Obstet Gynecol. 1992 Aug; 80(2):223-8.OG

Abstract

OBJECTIVE

We sought to determine a reference range for urinary immunoreactive beta core fragment of hCG (beta C-hCG) in pregnancy, the ratio between beta C-hCG and intact hCG, and the earliest detectable rise of beta C-hCG in urine.

METHODS

Urine was obtained from 741 pregnant women between 6-41 weeks' gestation, as well as from women undergoing donor insemination with timed ovulation peaks.

RESULTS

The beta core fragment of hCG reached a maximum between 8-15 weeks, with a decrease between 20-29 weeks. The molar ratio of beta C-hCG to intact hCG was always greater than 1.

CONCLUSION

In pregnancy, beta C-hCG concentrations increase in the urine in parallel to intact hCG but at a higher molar ratio, suggesting either placental production of beta C-hCG or enhanced metabolism of hCG to beta C-hCG in peripheral organs.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Adelaide, Queen Elizabeth Hospital, Woodville, South Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1378955

Citation

de Medeiros, S F., et al. "Urinary Concentrations of Beta Core Fragment of hCG Throughout Pregnancy." Obstetrics and Gynecology, vol. 80, no. 2, 1992, pp. 223-8.
de Medeiros SF, Amato F, Matthews CD, et al. Urinary concentrations of beta core fragment of hCG throughout pregnancy. Obstet Gynecol. 1992;80(2):223-8.
de Medeiros, S. F., Amato, F., Matthews, C. D., & Norman, R. J. (1992). Urinary concentrations of beta core fragment of hCG throughout pregnancy. Obstetrics and Gynecology, 80(2), 223-8.
de Medeiros SF, et al. Urinary Concentrations of Beta Core Fragment of hCG Throughout Pregnancy. Obstet Gynecol. 1992;80(2):223-8. PubMed PMID: 1378955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary concentrations of beta core fragment of hCG throughout pregnancy. AU - de Medeiros,S F, AU - Amato,F, AU - Matthews,C D, AU - Norman,R J, PY - 1992/8/1/pubmed PY - 1992/8/1/medline PY - 1992/8/1/entrez SP - 223 EP - 8 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 80 IS - 2 N2 - OBJECTIVE: We sought to determine a reference range for urinary immunoreactive beta core fragment of hCG (beta C-hCG) in pregnancy, the ratio between beta C-hCG and intact hCG, and the earliest detectable rise of beta C-hCG in urine. METHODS: Urine was obtained from 741 pregnant women between 6-41 weeks' gestation, as well as from women undergoing donor insemination with timed ovulation peaks. RESULTS: The beta core fragment of hCG reached a maximum between 8-15 weeks, with a decrease between 20-29 weeks. The molar ratio of beta C-hCG to intact hCG was always greater than 1. CONCLUSION: In pregnancy, beta C-hCG concentrations increase in the urine in parallel to intact hCG but at a higher molar ratio, suggesting either placental production of beta C-hCG or enhanced metabolism of hCG to beta C-hCG in peripheral organs. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/1378955/Urinary_concentrations_of_beta_core_fragment_of_hCG_throughout_pregnancy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=1378955.ui DB - PRIME DP - Unbound Medicine ER -