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Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species.
J Neuroimmunol 1992; 39(3):243-50JN

Abstract

We have been investigating the suppression of experimental autoimmune encephalomyelitis (EAE) by oral tolerization to autoantigens. In the present study the tolerizing effect of orally administered myelin basic protein (MBP) from different species was examined in the Lewis rat, Hartley guinea pig, and SJL/J mouse model of EAE. Animals were fed guinea pig, rat, bovine, human or mouse-MBP and then immunized with the homologous species of MBP or myelin: Lewis rats were immunized with rat MBP, Hartley guinea pigs with guinea pig-MBP, and SJL/J mice with mouse myelin. Clinical expression of EAE and delayed-type hypersensitivity (DTH) responses to MBP were assessed. In each species, suppression of disease and DTH responses were most pronounced by tolerization with the homologous species of MBP. In addition, cross-species tolerization was observed in each species and in general was less suppressive than homologous MBP although in some instances MBP from a heterologous species was as effective as tolerization with the homologous species. We also studied guinea pig-MBP induced EAE in the Lewis rat because it is a widely studied model of EAE and found that oral tolerization with guinea pig MBP was as suppressive as rat MBP. Of note is that oral tolerization with mouse MBP suppressed myelin-induced EAE in the SJL mouse in which autoimmunity to proteolipid protein appears to play a primary role, suggesting that antigen-driven bystander suppression following oral tolerization with autoantigens (Miller et al., 1991b) may be an important contributing mechanism for suppression of EAE following oral tolerization with MBP in this model.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1379607

Citation

Miller, A, et al. "Suppression of Experimental Autoimmune Encephalomyelitis By Oral Administration of Myelin Basic Protein. V. Hierarchy of Suppression By Myelin Basic Protein From Different Species." Journal of Neuroimmunology, vol. 39, no. 3, 1992, pp. 243-50.
Miller A, Lider O, al-Sabbagh A, et al. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species. J Neuroimmunol. 1992;39(3):243-50.
Miller, A., Lider, O., al-Sabbagh, A., & Weiner, H. L. (1992). Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species. Journal of Neuroimmunology, 39(3), pp. 243-50.
Miller A, et al. Suppression of Experimental Autoimmune Encephalomyelitis By Oral Administration of Myelin Basic Protein. V. Hierarchy of Suppression By Myelin Basic Protein From Different Species. J Neuroimmunol. 1992;39(3):243-50. PubMed PMID: 1379607.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species. AU - Miller,A, AU - Lider,O, AU - al-Sabbagh,A, AU - Weiner,H L, PY - 1992/8/1/pubmed PY - 2000/6/1/medline PY - 1992/8/1/entrez SP - 243 EP - 50 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 39 IS - 3 N2 - We have been investigating the suppression of experimental autoimmune encephalomyelitis (EAE) by oral tolerization to autoantigens. In the present study the tolerizing effect of orally administered myelin basic protein (MBP) from different species was examined in the Lewis rat, Hartley guinea pig, and SJL/J mouse model of EAE. Animals were fed guinea pig, rat, bovine, human or mouse-MBP and then immunized with the homologous species of MBP or myelin: Lewis rats were immunized with rat MBP, Hartley guinea pigs with guinea pig-MBP, and SJL/J mice with mouse myelin. Clinical expression of EAE and delayed-type hypersensitivity (DTH) responses to MBP were assessed. In each species, suppression of disease and DTH responses were most pronounced by tolerization with the homologous species of MBP. In addition, cross-species tolerization was observed in each species and in general was less suppressive than homologous MBP although in some instances MBP from a heterologous species was as effective as tolerization with the homologous species. We also studied guinea pig-MBP induced EAE in the Lewis rat because it is a widely studied model of EAE and found that oral tolerization with guinea pig MBP was as suppressive as rat MBP. Of note is that oral tolerization with mouse MBP suppressed myelin-induced EAE in the SJL mouse in which autoimmunity to proteolipid protein appears to play a primary role, suggesting that antigen-driven bystander suppression following oral tolerization with autoantigens (Miller et al., 1991b) may be an important contributing mechanism for suppression of EAE following oral tolerization with MBP in this model.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0165-5728 UR - https://www.unboundmedicine.com/medline/citation/1379607/Suppression_of_experimental_autoimmune_encephalomyelitis_by_oral_administration_of_myelin_basic_protein__V__Hierarchy_of_suppression_by_myelin_basic_protein_from_different_species_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0165-5728(92)90258-M DB - PRIME DP - Unbound Medicine ER -