Tags

Type your tag names separated by a space and hit enter

Tolerance mechanism in experimental ovarian and gastric autoimmune diseases.
J Immunol 1992; 149(6):2212-8JI

Abstract

Neonatal splenocytes, neonatal thymocytes, or phenotypically mature adult thymocytes, transferred from normal BALB/c mice to syngeneic athymic nu/nu (or SCID) mice, led to autoimmune oophoritis and autoimmune gastritis, with corresponding serum autoantibodies, in the recipients. The overall disease incidence was 73%; the pathology ranged from mild to severe, with complete loss of ovarian follicles and gastric parietal cells. CD4+ neonatal spleen cells and CD4+ CD8- adult thymocytes were required for autoimmune disease induction. Adult spleen cells did not elicit disease, but they prevented disease when co-transferred with neonatal spleen cells. However, in confirmation of an earlier report by Sakaguchi et al., (J. Exp. Med. 161:72, 1985), a subset of adult splenic T cells expressing a low level of CD5 molecules elicited similar autoimmune diseases. Thus, self-reactive T cells responsible for autoimmune disease of the stomach and ovary are not effectively deleted in the thymus, and they exist in the peripheral lymphoid organs of normal mice. We conclude that the functional expression of the self-reactive T cells is ontogenetically regulated; whereas T cells in the neonatal mice readily elicited autoimmune diseases in nu/nu recipients, regulatory cells may render self-reactive T cells in the normal adults unresponsive.

Authors+Show Affiliations

Department of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1381401

Citation

Smith, H, et al. "Tolerance Mechanism in Experimental Ovarian and Gastric Autoimmune Diseases." Journal of Immunology (Baltimore, Md. : 1950), vol. 149, no. 6, 1992, pp. 2212-8.
Smith H, Lou YH, Lacy P, et al. Tolerance mechanism in experimental ovarian and gastric autoimmune diseases. J Immunol. 1992;149(6):2212-8.
Smith, H., Lou, Y. H., Lacy, P., & Tung, K. S. (1992). Tolerance mechanism in experimental ovarian and gastric autoimmune diseases. Journal of Immunology (Baltimore, Md. : 1950), 149(6), pp. 2212-8.
Smith H, et al. Tolerance Mechanism in Experimental Ovarian and Gastric Autoimmune Diseases. J Immunol. 1992 Sep 15;149(6):2212-8. PubMed PMID: 1381401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tolerance mechanism in experimental ovarian and gastric autoimmune diseases. AU - Smith,H, AU - Lou,Y H, AU - Lacy,P, AU - Tung,K S, PY - 1992/9/15/pubmed PY - 1992/9/15/medline PY - 1992/9/15/entrez SP - 2212 EP - 8 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J. Immunol. VL - 149 IS - 6 N2 - Neonatal splenocytes, neonatal thymocytes, or phenotypically mature adult thymocytes, transferred from normal BALB/c mice to syngeneic athymic nu/nu (or SCID) mice, led to autoimmune oophoritis and autoimmune gastritis, with corresponding serum autoantibodies, in the recipients. The overall disease incidence was 73%; the pathology ranged from mild to severe, with complete loss of ovarian follicles and gastric parietal cells. CD4+ neonatal spleen cells and CD4+ CD8- adult thymocytes were required for autoimmune disease induction. Adult spleen cells did not elicit disease, but they prevented disease when co-transferred with neonatal spleen cells. However, in confirmation of an earlier report by Sakaguchi et al., (J. Exp. Med. 161:72, 1985), a subset of adult splenic T cells expressing a low level of CD5 molecules elicited similar autoimmune diseases. Thus, self-reactive T cells responsible for autoimmune disease of the stomach and ovary are not effectively deleted in the thymus, and they exist in the peripheral lymphoid organs of normal mice. We conclude that the functional expression of the self-reactive T cells is ontogenetically regulated; whereas T cells in the neonatal mice readily elicited autoimmune diseases in nu/nu recipients, regulatory cells may render self-reactive T cells in the normal adults unresponsive. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/1381401/Tolerance_mechanism_in_experimental_ovarian_and_gastric_autoimmune_diseases_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=1381401 DB - PRIME DP - Unbound Medicine ER -