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The influence of combined cyproterone acetate-ethinyl oestradiol therapy on serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women.
Acta Endocrinol (Copenh). 1977 Feb; 84(2):333-42.AE

Abstract

Serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women suffering from either idiopathic hirsutism or the polycystic ovary syndrome were determined before and during treatment with cyproterone acetate combined with ethinyl oestradiol. During this treatment the hirsutism decreased markedly. In untreated hirsute women serum dehydroepiandrosterone levels do not differ from those in normal women and do not change during therapy; androstenedione levels are higher than normal and decrease markedly during treatment, and the testosterone levels are elevated compared to normals, with a considerable overlap, and show only a tendency to decrease. There is no correlation between dehydroepiandrosterone and androstenedione levels or between androstenedione and testosterone levels in the serum of untreated hirsute women. After 12-14 months of cyproterone acetate-ethinyl oestradiol therapy a linear correlation is found between dehydroepiandrosterone and androstenedione levels. This can be explained by the relatively higher contribution of the peripheral conversion of dehydroepiandrosterone to androstenedione to the occurrence of lower androstenedione levels. The linear correlation between androstenedione and testosterone after treatment, also found in normal women, indicates the restoration of the role of androstenedione as the major peripheral precursor of testosterone.

Authors

Frölich M
No affiliation info available
Lachinsky N
No affiliation info available
Moolenaar AJ
No affiliation info available

MeSH

AdolescentAdultAndrostenedioneCyproteroneDehydroepiandrosteroneDrug Therapy, CombinationEthinyl EstradiolFemaleHirsutismHumansMiddle AgedPolycystic Ovary SyndromeTestosterone

Pub Type(s)

Journal Article

Language

eng

PubMed ID

138326

Citation

Frölich, M, et al. "The Influence of Combined Cyproterone Acetate-ethinyl Oestradiol Therapy On Serum Levels of Dehydroepiandrosterone, Androstenedione, and Testosterone in Hirsute Women." Acta Endocrinologica, vol. 84, no. 2, 1977, pp. 333-42.
Frölich M, Lachinsky N, Moolenaar AJ. The influence of combined cyproterone acetate-ethinyl oestradiol therapy on serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women. Acta Endocrinol (Copenh). 1977;84(2):333-42.
Frölich, M., Lachinsky, N., & Moolenaar, A. J. (1977). The influence of combined cyproterone acetate-ethinyl oestradiol therapy on serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women. Acta Endocrinologica, 84(2), 333-42.
Frölich M, Lachinsky N, Moolenaar AJ. The Influence of Combined Cyproterone Acetate-ethinyl Oestradiol Therapy On Serum Levels of Dehydroepiandrosterone, Androstenedione, and Testosterone in Hirsute Women. Acta Endocrinol (Copenh). 1977;84(2):333-42. PubMed PMID: 138326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of combined cyproterone acetate-ethinyl oestradiol therapy on serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women. AU - Frölich,M, AU - Lachinsky,N, AU - Moolenaar,A J, PY - 1977/2/1/pubmed PY - 1977/2/1/medline PY - 1977/2/1/entrez KW - Androgens--analysis KW - Biology KW - Clinical Research KW - Contraception KW - Contraceptive Agents, Estrogen--administraction and dosage KW - Contraceptive Agents, Estrogen--therapeutic use KW - Contraceptive Agents, Female--administraction and dosage KW - Contraceptive Agents, Female--therapeutic use KW - Contraceptive Agents--administraction and dosage KW - Contraceptive Agents--therapeutic use KW - Cyproterone Acetate--administraction and dosage KW - Cyproterone Acetate--therapeutic use KW - Dehydroepiandrosterone--analysis KW - Diseases KW - Endocrine System KW - Ethinyl Estradiol--administraction and dosage KW - Ethinyl Estradiol--therapeutic use KW - Family Planning KW - Hirsutism KW - Hormone Antagonists KW - Hormones KW - Ovarian Cysts KW - Physiology KW - Research Methodology KW - Signs And Symptoms KW - Testosterone--analysis SP - 333 EP - 42 JF - Acta endocrinologica JO - Acta Endocrinol (Copenh) VL - 84 IS - 2 N2 - Serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women suffering from either idiopathic hirsutism or the polycystic ovary syndrome were determined before and during treatment with cyproterone acetate combined with ethinyl oestradiol. During this treatment the hirsutism decreased markedly. In untreated hirsute women serum dehydroepiandrosterone levels do not differ from those in normal women and do not change during therapy; androstenedione levels are higher than normal and decrease markedly during treatment, and the testosterone levels are elevated compared to normals, with a considerable overlap, and show only a tendency to decrease. There is no correlation between dehydroepiandrosterone and androstenedione levels or between androstenedione and testosterone levels in the serum of untreated hirsute women. After 12-14 months of cyproterone acetate-ethinyl oestradiol therapy a linear correlation is found between dehydroepiandrosterone and androstenedione levels. This can be explained by the relatively higher contribution of the peripheral conversion of dehydroepiandrosterone to androstenedione to the occurrence of lower androstenedione levels. The linear correlation between androstenedione and testosterone after treatment, also found in normal women, indicates the restoration of the role of androstenedione as the major peripheral precursor of testosterone. SN - 0001-5598 UR - https://www.unboundmedicine.com/medline/citation/138326/The_influence_of_combined_cyproterone_acetate_ethinyl_oestradiol_therapy_on_serum_levels_of_dehydroepiandrosterone_androstenedione_and_testosterone_in_hirsute_women_ DB - PRIME DP - Unbound Medicine ER -