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Alterations in erythrocyte membrane fluidity in children with trisomy 21: a fluorescence study.
Biol Cell. 1992; 75(2):135-8.BC

Abstract

Membrane fluidity of erythrocytes obtained from 15 children with trisomy 21 and 20 healthy controls were studied by measuring steady-state fluorescence anisotropy and fluorescence lifetime of 1,6-diphenyl-1,3,5-hexatriene (DPH) and 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) incorporated in hemoglobin-free erythrocyte membranes. Our results demonstrate a significant decrease in DPH fluorescence anisotropy and a significant increase in TMA-DPH fluorescence anistropy in erythrocytes from subjects with trisomy 21. No significant differences between the two groups were observed in the fluorescence lifetime of DPH and TMA-DPH. These data suggest an increase in membrane fluidity in the interior part of the membrane and a decrease in fluidity at the lipid-water interface region. This could be in part attributed to an increased oxidative damage in trisomy 21.

Authors+Show Affiliations

Department of Pediatrics, University of Ancona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1393150

Citation

Kantar, A, et al. "Alterations in Erythrocyte Membrane Fluidity in Children With Trisomy 21: a Fluorescence Study." Biology of the Cell, vol. 75, no. 2, 1992, pp. 135-8.
Kantar A, Giorgi PL, Curatola G, et al. Alterations in erythrocyte membrane fluidity in children with trisomy 21: a fluorescence study. Biol Cell. 1992;75(2):135-8.
Kantar, A., Giorgi, P. L., Curatola, G., & Fiorini, R. (1992). Alterations in erythrocyte membrane fluidity in children with trisomy 21: a fluorescence study. Biology of the Cell, 75(2), 135-8.
Kantar A, et al. Alterations in Erythrocyte Membrane Fluidity in Children With Trisomy 21: a Fluorescence Study. Biol Cell. 1992;75(2):135-8. PubMed PMID: 1393150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations in erythrocyte membrane fluidity in children with trisomy 21: a fluorescence study. AU - Kantar,A, AU - Giorgi,P L, AU - Curatola,G, AU - Fiorini,R, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 135 EP - 8 JF - Biology of the cell JO - Biol Cell VL - 75 IS - 2 N2 - Membrane fluidity of erythrocytes obtained from 15 children with trisomy 21 and 20 healthy controls were studied by measuring steady-state fluorescence anisotropy and fluorescence lifetime of 1,6-diphenyl-1,3,5-hexatriene (DPH) and 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) incorporated in hemoglobin-free erythrocyte membranes. Our results demonstrate a significant decrease in DPH fluorescence anisotropy and a significant increase in TMA-DPH fluorescence anistropy in erythrocytes from subjects with trisomy 21. No significant differences between the two groups were observed in the fluorescence lifetime of DPH and TMA-DPH. These data suggest an increase in membrane fluidity in the interior part of the membrane and a decrease in fluidity at the lipid-water interface region. This could be in part attributed to an increased oxidative damage in trisomy 21. SN - 0248-4900 UR - https://www.unboundmedicine.com/medline/citation/1393150/Alterations_in_erythrocyte_membrane_fluidity_in_children_with_trisomy_21:_a_fluorescence_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0248-4900&date=1992&volume=75&issue=2&spage=135 DB - PRIME DP - Unbound Medicine ER -