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Acute effect of dialysate calcium concentration and intravenous vitamin D3 on the secretion of parathyroid hormone in hemodialysis patients.
Clin Nephrol. 1992 Sep; 38(3):145-8.CN

Abstract

We studied the suppression of intact parathyroid hormone (PTH) in ten patients on chronic hemodialysis using different calcium concentrations of dialysate. Secondly, giving i.v. vitamin D3 at commencement of dialysis we investigated whether 1 alpha (OH)D3 or 1,25(OH)2D3 acutely modifies the responsiveness of the parathyroid gland to the suppressive effect of increased serum calcium. Dialysis with high-calcium dialysate (1.75 mmol/l) reverted the plasma PTH to normal limits. Lower-calcium dialysate (1.5 mmol/l) induced only a partial suppression of hyperparathyroidism. We found no differences in the suppression of hyperparathyroidism whether 1 alpha (OH)D3 or 1,25(OH)2D3 was given at the beginning of the dialysis or not. We conclude that the suppressibility of hyperparathyroidism in dialysis patients can be evaluated by different calcium concentrations of dialysate, and that i.v. vitamin D3 does not acutely modify the responsiveness of the parathyroid gland to the effect of calcium.

Authors+Show Affiliations

Department of Medicine, Tampere University Hospital, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1395167

Citation

Saha, H, et al. "Acute Effect of Dialysate Calcium Concentration and Intravenous Vitamin D3 On the Secretion of Parathyroid Hormone in Hemodialysis Patients." Clinical Nephrology, vol. 38, no. 3, 1992, pp. 145-8.
Saha H, Pietilä K, Mustonen J, et al. Acute effect of dialysate calcium concentration and intravenous vitamin D3 on the secretion of parathyroid hormone in hemodialysis patients. Clin Nephrol. 1992;38(3):145-8.
Saha, H., Pietilä, K., Mustonen, J., Pasternack, A., & Mörsky, P. (1992). Acute effect of dialysate calcium concentration and intravenous vitamin D3 on the secretion of parathyroid hormone in hemodialysis patients. Clinical Nephrology, 38(3), 145-8.
Saha H, et al. Acute Effect of Dialysate Calcium Concentration and Intravenous Vitamin D3 On the Secretion of Parathyroid Hormone in Hemodialysis Patients. Clin Nephrol. 1992;38(3):145-8. PubMed PMID: 1395167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effect of dialysate calcium concentration and intravenous vitamin D3 on the secretion of parathyroid hormone in hemodialysis patients. AU - Saha,H, AU - Pietilä,K, AU - Mustonen,J, AU - Pasternack,A, AU - Mörsky,P, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 145 EP - 8 JF - Clinical nephrology JO - Clin. Nephrol. VL - 38 IS - 3 N2 - We studied the suppression of intact parathyroid hormone (PTH) in ten patients on chronic hemodialysis using different calcium concentrations of dialysate. Secondly, giving i.v. vitamin D3 at commencement of dialysis we investigated whether 1 alpha (OH)D3 or 1,25(OH)2D3 acutely modifies the responsiveness of the parathyroid gland to the suppressive effect of increased serum calcium. Dialysis with high-calcium dialysate (1.75 mmol/l) reverted the plasma PTH to normal limits. Lower-calcium dialysate (1.5 mmol/l) induced only a partial suppression of hyperparathyroidism. We found no differences in the suppression of hyperparathyroidism whether 1 alpha (OH)D3 or 1,25(OH)2D3 was given at the beginning of the dialysis or not. We conclude that the suppressibility of hyperparathyroidism in dialysis patients can be evaluated by different calcium concentrations of dialysate, and that i.v. vitamin D3 does not acutely modify the responsiveness of the parathyroid gland to the effect of calcium. SN - 0301-0430 UR - https://www.unboundmedicine.com/medline/citation/1395167/Acute_effect_of_dialysate_calcium_concentration_and_intravenous_vitamin_D3_on_the_secretion_of_parathyroid_hormone_in_hemodialysis_patients_ L2 - https://medlineplus.gov/dialysis.html DB - PRIME DP - Unbound Medicine ER -