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[Otilonium bromide-diazepam in the treatment of the irritable colon. A controlled study versus otilonium bromide].
Clin Ter. 1992 Aug; 141(8):129-34.CT

Abstract

Octylonium bromide (OB) is a drug with spasmolytic properties acting selectively on the smooth muscle of the gastrointestinal tract by interfering with calcium mobilization from extra- and intra-cellular deposits. The etiopathogenetic implications of a psychosomatic nature of the irritable bowel syndrome amply justify the use of a spasmolytic (OB) with a benzodiazepine. In our study, we compared the combination OB + DZ (20 mg + 2 mg) T.I.D. versus OB alone (20 mg) in 30 patients suffering from irritable bowel syndrome. The double-blind study lasting 3 weeks was aimed at evaluating gastrointestinal symptoms (bowel motions, aspect of faeces, abdominal pain, pre-evacuation pain, bloating) during the three days preceding the study and during the last five days of treatment, as well as the anxiogenic situation as assessed by the STAI scale (State Tract Anxiety Inventory) before and at the end of the treatment period. The results obtained showed that both treatments considerably reduced gastrointestinal symptoms even though OB alone did not appear to be equally effective and the anxiety component was significantly reduced only by treatment with the combination. The absence of side effects and the perfect tolerability of both treatments showed the OB + D combination T.I.D. to be the treatment of choice for patients suffering from irritable bowel syndrome.

Authors+Show Affiliations

Divisione di Gastroenterologia, Ospedale Ferrari, Castrovillari, CZ.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

ita

PubMed ID

1395455

Citation

Mollica, G, and G Manno. "[Otilonium Bromide-diazepam in the Treatment of the Irritable Colon. a Controlled Study Versus Otilonium Bromide]." La Clinica Terapeutica, vol. 141, no. 8, 1992, pp. 129-34.
Mollica G, Manno G. [Otilonium bromide-diazepam in the treatment of the irritable colon. A controlled study versus otilonium bromide]. Clin Ter. 1992;141(8):129-34.
Mollica, G., & Manno, G. (1992). [Otilonium bromide-diazepam in the treatment of the irritable colon. A controlled study versus otilonium bromide]. La Clinica Terapeutica, 141(8), 129-34.
Mollica G, Manno G. [Otilonium Bromide-diazepam in the Treatment of the Irritable Colon. a Controlled Study Versus Otilonium Bromide]. Clin Ter. 1992;141(8):129-34. PubMed PMID: 1395455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Otilonium bromide-diazepam in the treatment of the irritable colon. A controlled study versus otilonium bromide]. AU - Mollica,G, AU - Manno,G, PY - 1992/8/1/pubmed PY - 1992/8/1/medline PY - 1992/8/1/entrez SP - 129 EP - 34 JF - La Clinica terapeutica JO - Clin Ter VL - 141 IS - 8 N2 - Octylonium bromide (OB) is a drug with spasmolytic properties acting selectively on the smooth muscle of the gastrointestinal tract by interfering with calcium mobilization from extra- and intra-cellular deposits. The etiopathogenetic implications of a psychosomatic nature of the irritable bowel syndrome amply justify the use of a spasmolytic (OB) with a benzodiazepine. In our study, we compared the combination OB + DZ (20 mg + 2 mg) T.I.D. versus OB alone (20 mg) in 30 patients suffering from irritable bowel syndrome. The double-blind study lasting 3 weeks was aimed at evaluating gastrointestinal symptoms (bowel motions, aspect of faeces, abdominal pain, pre-evacuation pain, bloating) during the three days preceding the study and during the last five days of treatment, as well as the anxiogenic situation as assessed by the STAI scale (State Tract Anxiety Inventory) before and at the end of the treatment period. The results obtained showed that both treatments considerably reduced gastrointestinal symptoms even though OB alone did not appear to be equally effective and the anxiety component was significantly reduced only by treatment with the combination. The absence of side effects and the perfect tolerability of both treatments showed the OB + D combination T.I.D. to be the treatment of choice for patients suffering from irritable bowel syndrome. SN - 0009-9074 UR - https://www.unboundmedicine.com/medline/citation/1395455/[Otilonium_bromide_diazepam_in_the_treatment_of_the_irritable_colon__A_controlled_study_versus_otilonium_bromide]_ DB - PRIME DP - Unbound Medicine ER -