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Sickle cell leg ulcers in Ghana.
East Afr Med J 1992; 69(7):366-9EA

Abstract

Twenty five (17 male, 8 Female) sickle cell disease patients with 30 leg ulcers were studied over a 3 year period (January 1985 to December 1987) to provide information on the pathogenesis, course and management. There were 23 patients with homozygous sickle cell and 2 patients with sickle cell haemoglobin C disease. The mean age was 28 years (range 15-44 years). An antecedent history of trauma was obtained in 40% of the patients and 96% had a previous history of leg ulcer. The major site affected (93%) was the skin around the malleoli. In 68% of the patients a single organism was isolated and the commonest bacteria were Pseudomonas species, Staphylococcus aureus, Proteus species and B haemolytic streptococci. The major complications encountered were equinovarus deformity (36%) and chronic periosteitis (32%). The main topical antimicrobial used was Eusol either alone (52%) or in combination with Metronidazole (32%) or honey (12%). Complete healing occurred in 40% of patients, partial healing with deterioration in 16% and no significant change in 44%. Admission and bed rest were the best determinants of complete healing of the chronic ulcers.

Authors+Show Affiliations

Department of Haematology, University of Ghana Medical School, Accra.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1396190

Citation

Ankra-Badu, G A.. "Sickle Cell Leg Ulcers in Ghana." East African Medical Journal, vol. 69, no. 7, 1992, pp. 366-9.
Ankra-Badu GA. Sickle cell leg ulcers in Ghana. East Afr Med J. 1992;69(7):366-9.
Ankra-Badu, G. A. (1992). Sickle cell leg ulcers in Ghana. East African Medical Journal, 69(7), pp. 366-9.
Ankra-Badu GA. Sickle Cell Leg Ulcers in Ghana. East Afr Med J. 1992;69(7):366-9. PubMed PMID: 1396190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sickle cell leg ulcers in Ghana. A1 - Ankra-Badu,G A, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 366 EP - 9 JF - East African medical journal JO - East Afr Med J VL - 69 IS - 7 N2 - Twenty five (17 male, 8 Female) sickle cell disease patients with 30 leg ulcers were studied over a 3 year period (January 1985 to December 1987) to provide information on the pathogenesis, course and management. There were 23 patients with homozygous sickle cell and 2 patients with sickle cell haemoglobin C disease. The mean age was 28 years (range 15-44 years). An antecedent history of trauma was obtained in 40% of the patients and 96% had a previous history of leg ulcer. The major site affected (93%) was the skin around the malleoli. In 68% of the patients a single organism was isolated and the commonest bacteria were Pseudomonas species, Staphylococcus aureus, Proteus species and B haemolytic streptococci. The major complications encountered were equinovarus deformity (36%) and chronic periosteitis (32%). The main topical antimicrobial used was Eusol either alone (52%) or in combination with Metronidazole (32%) or honey (12%). Complete healing occurred in 40% of patients, partial healing with deterioration in 16% and no significant change in 44%. Admission and bed rest were the best determinants of complete healing of the chronic ulcers. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/1396190/Sickle_cell_leg_ulcers_in_Ghana_ L2 - https://medlineplus.gov/leginjuriesanddisorders.html DB - PRIME DP - Unbound Medicine ER -