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[Fatal course of peracute fatty liver of pregnancy].
Geburtshilfe Frauenheilkd. 1992 Sep; 52(9):564-7.GF

Abstract

A fatal case of acute fatty liver of pregnancy (AFLP) is reported. After admission, the patient was delivered within 3 hours. Routine laboratory investigation revealed acute liver insufficiency with advanced coagulopathy. Despite substitution therapy, the severe coagulation defect progressed to lethal intracerebral bleeding. Advanced AFLP can only be satisfactorily diagnosed in time, if non-specific symptoms or icterus lead to studies of blood chemistry, especially liver function tests, coagulation parameters (including platelet count, fibrinogen, AT III), blood glucose and renal function (including uric acid). This will enable an adequate management of the patient. The clinical problem of AFLP still remains that of early diagnosis.

Authors+Show Affiliations

Fischer J
Universitätsfrauenklinik Tübingen.
Rozenbajgier C
No affiliation info available
Schulze M
No affiliation info available
Decker K
No affiliation info available
Stoll P
No affiliation info available

MeSH

Acute DiseaseAdultDiagnosis, DifferentialFatty LiverFemaleHELLP SyndromeHumansInfant, NewbornLiverMaleObstetric Labor ComplicationsPostpartum HemorrhagePregnancyPregnancy ComplicationsPregnancy, MultipleUterine Inertia

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

1397961

Citation

Fischer, J, et al. "[Fatal Course of Peracute Fatty Liver of Pregnancy]." Geburtshilfe Und Frauenheilkunde, vol. 52, no. 9, 1992, pp. 564-7.
Fischer J, Rozenbajgier C, Schulze M, et al. [Fatal course of peracute fatty liver of pregnancy]. Geburtshilfe Frauenheilkd. 1992;52(9):564-7.
Fischer, J., Rozenbajgier, C., Schulze, M., Decker, K., & Stoll, P. (1992). [Fatal course of peracute fatty liver of pregnancy]. Geburtshilfe Und Frauenheilkunde, 52(9), 564-7.
Fischer J, et al. [Fatal Course of Peracute Fatty Liver of Pregnancy]. Geburtshilfe Frauenheilkd. 1992;52(9):564-7. PubMed PMID: 1397961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Fatal course of peracute fatty liver of pregnancy]. AU - Fischer,J, AU - Rozenbajgier,C, AU - Schulze,M, AU - Decker,K, AU - Stoll,P, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 564 EP - 7 JF - Geburtshilfe und Frauenheilkunde JO - Geburtshilfe Frauenheilkd VL - 52 IS - 9 N2 - A fatal case of acute fatty liver of pregnancy (AFLP) is reported. After admission, the patient was delivered within 3 hours. Routine laboratory investigation revealed acute liver insufficiency with advanced coagulopathy. Despite substitution therapy, the severe coagulation defect progressed to lethal intracerebral bleeding. Advanced AFLP can only be satisfactorily diagnosed in time, if non-specific symptoms or icterus lead to studies of blood chemistry, especially liver function tests, coagulation parameters (including platelet count, fibrinogen, AT III), blood glucose and renal function (including uric acid). This will enable an adequate management of the patient. The clinical problem of AFLP still remains that of early diagnosis. SN - 0016-5751 UR - https://www.unboundmedicine.com/medline/citation/1397961/[Fatal_course_of_peracute_fatty_liver_of_pregnancy]_ DB - PRIME DP - Unbound Medicine ER -