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Effect of aminophylline on the pulmonary and systemic hemodynamic response to group B beta-hemolytic Streptococcus and leukotriene D4 in newborn lambs.
J Dev Physiol. 1992 Apr; 17(4):195-200.JD

Abstract

Aminophylline, a methyl xanthine, has been used for many years in the treatment of apnea of prematurity and bronchospasm. Aminophylline relaxes smooth muscle through several proposed mechanisms. We hypothesized that aminophylline might be effective in relaxing preconstricted pulmonary vascular smooth muscle and would be ideally suited for clinical trial in babies with pulmonary hypertension. To test this hypothesis, the haemodynamic response of chronically instrumented newborn lambs to injections of heat-killed Group B beta-hemolytic Streptococcus (GBS) and leukotriene (LT) D4, potent pulmonary vasoconstrictors was compared before and after pretreatment with a clinically therapeutic dose of intravenous aminophylline. GBS (10(9)cfu) significantly increased pulmonary arterial pressure 130%. LTD4 (1.0 microgram/kg) significantly increased pulmonary arterial pressure 142% and systemic arterial pressure 23% and decreased cardiac output 47%. Aminophylline did not significantly affect the baseline variables or alter the pulmonary or systemic haemodynamic response to either stimuli. Therefore, it is unlikely that aminophylline will be clinically useful in the treatment of babies with persistent pulmonary hypertension whose etiology is infectious or leukotriene-mediated.

Authors+Show Affiliations

Department of Paediatrics, Pritzker School of Medicine, University of Chicago, Illinois.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1401781

Citation

Schreiber, M D., et al. "Effect of Aminophylline On the Pulmonary and Systemic Hemodynamic Response to Group B Beta-hemolytic Streptococcus and Leukotriene D4 in Newborn Lambs." Journal of Developmental Physiology, vol. 17, no. 4, 1992, pp. 195-200.
Schreiber MD, Covert RF, Torgerson LJ. Effect of aminophylline on the pulmonary and systemic hemodynamic response to group B beta-hemolytic Streptococcus and leukotriene D4 in newborn lambs. J Dev Physiol. 1992;17(4):195-200.
Schreiber, M. D., Covert, R. F., & Torgerson, L. J. (1992). Effect of aminophylline on the pulmonary and systemic hemodynamic response to group B beta-hemolytic Streptococcus and leukotriene D4 in newborn lambs. Journal of Developmental Physiology, 17(4), 195-200.
Schreiber MD, Covert RF, Torgerson LJ. Effect of Aminophylline On the Pulmonary and Systemic Hemodynamic Response to Group B Beta-hemolytic Streptococcus and Leukotriene D4 in Newborn Lambs. J Dev Physiol. 1992;17(4):195-200. PubMed PMID: 1401781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of aminophylline on the pulmonary and systemic hemodynamic response to group B beta-hemolytic Streptococcus and leukotriene D4 in newborn lambs. AU - Schreiber,M D, AU - Covert,R F, AU - Torgerson,L J, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 195 EP - 200 JF - Journal of developmental physiology JO - J Dev Physiol VL - 17 IS - 4 N2 - Aminophylline, a methyl xanthine, has been used for many years in the treatment of apnea of prematurity and bronchospasm. Aminophylline relaxes smooth muscle through several proposed mechanisms. We hypothesized that aminophylline might be effective in relaxing preconstricted pulmonary vascular smooth muscle and would be ideally suited for clinical trial in babies with pulmonary hypertension. To test this hypothesis, the haemodynamic response of chronically instrumented newborn lambs to injections of heat-killed Group B beta-hemolytic Streptococcus (GBS) and leukotriene (LT) D4, potent pulmonary vasoconstrictors was compared before and after pretreatment with a clinically therapeutic dose of intravenous aminophylline. GBS (10(9)cfu) significantly increased pulmonary arterial pressure 130%. LTD4 (1.0 microgram/kg) significantly increased pulmonary arterial pressure 142% and systemic arterial pressure 23% and decreased cardiac output 47%. Aminophylline did not significantly affect the baseline variables or alter the pulmonary or systemic haemodynamic response to either stimuli. Therefore, it is unlikely that aminophylline will be clinically useful in the treatment of babies with persistent pulmonary hypertension whose etiology is infectious or leukotriene-mediated. SN - 0141-9846 UR - https://www.unboundmedicine.com/medline/citation/1401781/Effect_of_aminophylline_on_the_pulmonary_and_systemic_hemodynamic_response_to_group_B_beta_hemolytic_Streptococcus_and_leukotriene_D4_in_newborn_lambs_ DB - PRIME DP - Unbound Medicine ER -