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Asymptomatic nerve hypertrophy in lepromatous leprosy: a clinical, electrophysiological and morphological study.
J Neurol. 1992 Aug; 239(7):367-74.JN

Abstract

In order to learn more about early nerve lesions observed in leprosy, we performed a clinical, electrophysiological and morphological study in seven patients with untreated lepromatous leprosy, palpably enlarged radial cutaneous nerve and preserved sensation in the corresponding territory. The conduction velocity of the cutaneous radial nerve, which was decreased in all patients, did not significantly differ from that of a group of patients with lepromatous leprosy, hypertrophy of the radial cutaneous nerve and sensory loss. In contrast, the sensory action potential was significantly lower in patients with sensory loss, which demonstrates that axon loss is more important than demyelination in producing sensory loss. In all patients nerve enlargement was due to thickening of the epineurium and of the perineurium subsequent to inflammatory infiltrates and proliferation of fibroblasts and perineurial cells. In several fascicles, the inflammatory infiltrates and the infected cells infiltrated endoneurial connective tissue septa and blood vessels. Mycobacteria leprae were abundant in perineurial cells, fibroblasts, macrophages, Schwann cells and endothelial cells, and lymphocytic vasculitis present in all cases. The average density of myelinated fibres was 2600 SD 880 fibres/mm2 (control: 7700 fibres/mm2), with marked differences between individual fascicles, versus 420 fibres/mm2 in patients with nerve hypertrophy and sensory loss (range 0-2080 fibres/mm2). Single fibre preparations showed that segmental demyelination predominated in two patients, axonal degeneration in one, while inflammatory infiltrates and proliferation of connective tissue adhering to individual fibres were prominent in the others.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Institut de Léprologie, Dakar, Senegal.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1403017

Citation

Tzourio, C, et al. "Asymptomatic Nerve Hypertrophy in Lepromatous Leprosy: a Clinical, Electrophysiological and Morphological Study." Journal of Neurology, vol. 239, no. 7, 1992, pp. 367-74.
Tzourio C, Said G, Millan J. Asymptomatic nerve hypertrophy in lepromatous leprosy: a clinical, electrophysiological and morphological study. J Neurol. 1992;239(7):367-74.
Tzourio, C., Said, G., & Millan, J. (1992). Asymptomatic nerve hypertrophy in lepromatous leprosy: a clinical, electrophysiological and morphological study. Journal of Neurology, 239(7), 367-74.
Tzourio C, Said G, Millan J. Asymptomatic Nerve Hypertrophy in Lepromatous Leprosy: a Clinical, Electrophysiological and Morphological Study. J Neurol. 1992;239(7):367-74. PubMed PMID: 1403017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymptomatic nerve hypertrophy in lepromatous leprosy: a clinical, electrophysiological and morphological study. AU - Tzourio,C, AU - Said,G, AU - Millan,J, PY - 1992/8/1/pubmed PY - 1992/8/1/medline PY - 1992/8/1/entrez SP - 367 EP - 74 JF - Journal of neurology JO - J Neurol VL - 239 IS - 7 N2 - In order to learn more about early nerve lesions observed in leprosy, we performed a clinical, electrophysiological and morphological study in seven patients with untreated lepromatous leprosy, palpably enlarged radial cutaneous nerve and preserved sensation in the corresponding territory. The conduction velocity of the cutaneous radial nerve, which was decreased in all patients, did not significantly differ from that of a group of patients with lepromatous leprosy, hypertrophy of the radial cutaneous nerve and sensory loss. In contrast, the sensory action potential was significantly lower in patients with sensory loss, which demonstrates that axon loss is more important than demyelination in producing sensory loss. In all patients nerve enlargement was due to thickening of the epineurium and of the perineurium subsequent to inflammatory infiltrates and proliferation of fibroblasts and perineurial cells. In several fascicles, the inflammatory infiltrates and the infected cells infiltrated endoneurial connective tissue septa and blood vessels. Mycobacteria leprae were abundant in perineurial cells, fibroblasts, macrophages, Schwann cells and endothelial cells, and lymphocytic vasculitis present in all cases. The average density of myelinated fibres was 2600 SD 880 fibres/mm2 (control: 7700 fibres/mm2), with marked differences between individual fascicles, versus 420 fibres/mm2 in patients with nerve hypertrophy and sensory loss (range 0-2080 fibres/mm2). Single fibre preparations showed that segmental demyelination predominated in two patients, axonal degeneration in one, while inflammatory infiltrates and proliferation of connective tissue adhering to individual fibres were prominent in the others.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0340-5354 UR - https://www.unboundmedicine.com/medline/citation/1403017/Asymptomatic_nerve_hypertrophy_in_lepromatous_leprosy:_a_clinical_electrophysiological_and_morphological_study_ DB - PRIME DP - Unbound Medicine ER -