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[Clinical diagnosis and neuropathologic examination findings in 20 AIDS patients].

Abstract

Disorders of the central nervous system (CNS) associated with HIV infections are becoming increasingly important in the area of clinical diagnosis and treatment of patients with AIDS. The aim of this retrospective analysis of 20 patients with AIDS who died in 1989 was to compare clinical diagnosis, neuroradiological findings and treatment with the results of neuropathological studies. The neuropathological examinations revealed primary CNS lymphoma (high-grade non-Hodgkin's lymphoma) in seven cases, cerebral toxoplasmosis in four cases, haemorrhagic infarction in three cases, cerebral cryptococcosis in three cases, and one case each of infiltration of the dura by a peripheral Burkitt's lymphoma, cytomegalovirus encephalitis and bacterial meningitis. A remarkably high percentage of CNS lymphomas with no distinct clinical or neuroradiological differentiation criteria were found in this study. On the basis of these data, we conclude that stereotactic biopsy and histological diagnosis should be recommended for patients with focal intracerebral lesions who fail to respond to suitable anti-parasitic treatment.

Authors+Show Affiliations

,

Klinische Abteilung, Bernhard-Nocht-Institut für Tropenmedizin, Hamburg.

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Source

MeSH

AIDS Dementia Complex
AIDS-Related Opportunistic Infections
Adult
Brain
Encephalitis
Female
Humans
Lymphoma, AIDS-Related
Male
Meningitis
Middle Aged
Toxoplasmosis, Cerebral

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

1406481

Citation

van Lunzen, J, et al. "[Clinical Diagnosis and Neuropathologic Examination Findings in 20 AIDS Patients]." Medizinische Klinik (Munich, Germany : 1983), vol. 87, no. 9, 1992, pp. 454-9.
van Lunzen J, Stavrou D, Reinhold S, et al. [Clinical diagnosis and neuropathologic examination findings in 20 AIDS patients]. Med Klin (Munich). 1992;87(9):454-9.
van Lunzen, J., Stavrou, D., Reinhold, S., Zanella, F., Racz, P., Gottesleben, A., & Kern, P. (1992). [Clinical diagnosis and neuropathologic examination findings in 20 AIDS patients]. Medizinische Klinik (Munich, Germany : 1983), 87(9), pp. 454-9.
van Lunzen J, et al. [Clinical Diagnosis and Neuropathologic Examination Findings in 20 AIDS Patients]. Med Klin (Munich). 1992 Sep 15;87(9):454-9. PubMed PMID: 1406481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical diagnosis and neuropathologic examination findings in 20 AIDS patients]. AU - van Lunzen,J, AU - Stavrou,D, AU - Reinhold,S, AU - Zanella,F, AU - Racz,P, AU - Gottesleben,A, AU - Kern,P, PY - 1992/9/15/pubmed PY - 2000/3/22/medline PY - 1992/9/15/entrez SP - 454 EP - 9 JF - Medizinische Klinik (Munich, Germany : 1983) JO - Med. Klin. (Munich) VL - 87 IS - 9 N2 - Disorders of the central nervous system (CNS) associated with HIV infections are becoming increasingly important in the area of clinical diagnosis and treatment of patients with AIDS. The aim of this retrospective analysis of 20 patients with AIDS who died in 1989 was to compare clinical diagnosis, neuroradiological findings and treatment with the results of neuropathological studies. The neuropathological examinations revealed primary CNS lymphoma (high-grade non-Hodgkin's lymphoma) in seven cases, cerebral toxoplasmosis in four cases, haemorrhagic infarction in three cases, cerebral cryptococcosis in three cases, and one case each of infiltration of the dura by a peripheral Burkitt's lymphoma, cytomegalovirus encephalitis and bacterial meningitis. A remarkably high percentage of CNS lymphomas with no distinct clinical or neuroradiological differentiation criteria were found in this study. On the basis of these data, we conclude that stereotactic biopsy and histological diagnosis should be recommended for patients with focal intracerebral lesions who fail to respond to suitable anti-parasitic treatment. SN - 0723-5003 UR - https://www.unboundmedicine.com/medline/citation/1406481/[Clinical_diagnosis_and_neuropathologic_examination_findings_in_20_AIDS_patients]_ L2 - http://www.diseaseinfosearch.org/result/279 DB - PRIME DP - Unbound Medicine ER -